5-chloro-2-iodo-1-methoxy-3-methylbenzene

Base Information

• Chemical Name: 5-chloro-2-iodo-1-methoxy-3-methylbenzene
• CAS No.: 1150617-68-7
• Molecular Formula: C₈H₈ClIO
• Molecular Weight: 282.508
• Mol file: 1150617-68-7.mol

Synonyms:5-chloro-2-iodo-1-methoxy-3-methylbenzene

Chemical Property of 5-chloro-2-iodo-1-methoxy-3-methylbenzene

Chemical Property:

• Boiling Point: 293.3±40.0 °C(Predicted)
• Density: 1.725±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

5-Chloro-2-iodo-1-methoxy-3-methylbenzene 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-2-iodo-1-methoxy-3-methylbenzene

There total 6 articles about 5-chloro-2-iodo-1-methoxy-3-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-chloro-2-methoxy-6-methylphenylamine (644961-69-3) → 5-chloro-2-iodo-1-methoxy-3-methylbenzene (1150617-68-7)

Guidance literature:

4-chloro-2-methoxy-6-methylphenylamine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.166667h;

With potassium iodide; In water; at 20 ℃;

Reference yield: 74.0%

5-chloro-2-iodo-3-methylphenol (1150617-66-5) + methyl iodide (74-88-4) → 5-chloro-2-iodo-1-methoxy-3-methylbenzene (1150617-68-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at 23 ℃; for 12h;

DOI:10.1021/jm200128m

Reference yield:

5-chloro-2-iodo-1-methyl-3-nitrobenzene (1150617-61-0) → 5-chloro-2-iodo-1-methoxy-3-methylbenzene (1150617-68-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: iron; ammonium chloride / ethanol; water / 0.5 h / Reflux

2.1: sulfuric acid; acetic acid; sodium nitrite / 0.5 h / 23 °C

2.2: Reflux

3.1: potassium carbonate / acetonitrile / 12 h / 23 °C

With sulfuric acid; iron; potassium carbonate; ammonium chloride; acetic acid; sodium nitrite; In ethanol; water; acetonitrile;

DOI:10.1021/jm200128m

upstream raw materials:

4-chloro-2-methoxy-6-methylphenylamine

5-chloro-2-iodo-1-methyl-3-nitrobenzene

5-chloro-2-iodo-3-methylphenylamine

5-chloro-2-iodo-3-methylphenol

Downstream raw materials:

2-(4-chloro-2-methoxy-6-methylphenyl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane

2-amino-4-{4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2,2-trifluoroethyl)amide

2-amino-4-{4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2-difluoropropyl)amide

2-amino-4-(4-chloro-2-hydroxy-6-methylphenyl)-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "2-AMINO PYRIMIDINE COMPOUNDS AS POTENT HSP-90 INHIBITORS". Page/Page column 24-25. . Retrieved 2010/03/04.