tert-butyl 4-(2-((1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-((1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazine-1-carboxylate
CAS No.:174855-59-5
Molecular Formula:C₁₈H₂₅N₅O₂
Molecular Weight:343.429
Hs Code.:

Synonyms:tert-butyl 4-(2-((1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazine-1-carboxylate

Suppliers and Price of tert-butyl 4-(2-((1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of tert-butyl 4-(2-((1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl 4-(2-((1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazine-1-carboxylate

There total 6 articles about tert-butyl 4-(2-((1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 41253-21-8
sodium triazole

: 209160-88-3
1-t-butoxycarbonyl-4-(2-(methanesulfonyloxymethyl)phenyl)-piperazine

: 174855-59-5
1-t-Butoxycarbonyl-4-(2-(1'-(1',2',4'-triazolyl)methyl)phenyl)-piperazine

Guidance literature:: In dichloromethane; at 25 ℃;
DOI:10.1016/S0960-894X(03)00796-0

Reference yield:

: 446-52-6
2-Fluorobenzaldehyde

: 174855-59-5
1-t-Butoxycarbonyl-4-(2-(1'-(1',2',4'-triazolyl)methyl)phenyl)-piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / K₂CO₃ / dimethylsulfoxide / 130 °C

2: 74 percent / NaBH₄ / methanol / 0 °C

3: 96 percent / Et₃N / 0 °C

4: 55 percent / CH₂Cl₂ / 25 °C

With sodium tetrahydroborate; potassium carbonate; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0960-894X(03)00796-0

Reference yield:

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 174855-59-5
1-t-Butoxycarbonyl-4-(2-(1'-(1',2',4'-triazolyl)methyl)phenyl)-piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / K₂CO₃ / dimethylsulfoxide / 130 °C

2: 74 percent / NaBH₄ / methanol / 0 °C

3: 96 percent / Et₃N / 0 °C

4: 55 percent / CH₂Cl₂ / 25 °C

With sodium tetrahydroborate; potassium carbonate; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0960-894X(03)00796-0