1-t-butoxycarbonyl-4-(2-(methanesulfonyloxymethyl)phenyl)-piperazine

Base Information

• Chemical Name: 1-t-butoxycarbonyl-4-(2-(methanesulfonyloxymethyl)phenyl)-piperazine
• CAS No.: 209160-88-3
• Molecular Formula: C₁₇H₂₆N₂O₅S
• Molecular Weight: 370.47
• Mol file: 209160-88-3.mol

Synonyms:1-t-butoxycarbonyl-4-(2-(methanesulfonyloxymethyl)phenyl)-piperazine

Chemical Property of 1-t-butoxycarbonyl-4-(2-(methanesulfonyloxymethyl)phenyl)-piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-t-butoxycarbonyl-4-(2-(methanesulfonyloxymethyl)phenyl)-piperazine

There total 9 articles about 1-t-butoxycarbonyl-4-(2-(methanesulfonyloxymethyl)phenyl)-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methanesulfonyl chloride (124-63-0) + 4-(2-(hydroxymethyl)phenyl)piperazine-1-carboxylic acid tert-butyl ester (179250-28-3) → 1-t-butoxycarbonyl-4-(2-(methanesulfonyloxymethyl)phenyl)-piperazine (209160-88-3)

Guidance literature:

With triethylamine; at 0 ℃;

DOI:10.1016/S0960-894X(03)00796-0

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 1-t-butoxycarbonyl-4-(2-(methanesulfonyloxymethyl)phenyl)-piperazine (209160-88-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 49.8 g / aq. NaHCO₃ / ethanol

2: BH₃ / tetrahydrofuran

3: triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 °C

With dmap; borane; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm0304109

Reference yield:

2-(piperazin-1-yl)benzonitrile (111373-03-6) → 1-t-butoxycarbonyl-4-(2-(methanesulfonyloxymethyl)phenyl)-piperazine (209160-88-3)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. KOH / ethanol / Heating

2: 49.8 g / aq. NaHCO₃ / ethanol

3: BH₃ / tetrahydrofuran

4: triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 °C

With dmap; potassium hydroxide; borane; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm0304109

upstream raw materials:

methanesulfonyl chloride

4-(2-(hydroxymethyl)phenyl)piperazine-1-carboxylic acid tert-butyl ester

di-tert-butyl dicarbonate

2-(piperazin-1-yl)benzonitrile

Downstream raw materials:

1-t-butoxycarbonyl-4-(2-(methylthiomethyl)phenyl)-piperazine

4-(2-[1,2,4]triazol-4-ylmethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

1-(2-(1'-(1',2',4'-triazolyl)-methyl)phenyl)-piperazine

1-tert-butoxycarbonyl-4-[2-((2-methylimidazol-1-yl)methyl)phenyl]piperazine