3-BROMO-4-BENZYLAMINOPYRIDINE

Base Information

• Chemical Name: 3-BROMO-4-BENZYLAMINOPYRIDINE
• CAS No.: 100953-53-5
• Molecular Formula: C₁₂H₁₁BrN₂
• Molecular Weight: 263.137
• Mol file: 100953-53-5.mol

Synonyms:3-BROMO-4-BENZYLAMINOPYRIDINE

Chemical Property of 3-BROMO-4-BENZYLAMINOPYRIDINE

Chemical Property:

• Boiling Point: 363.5±32.0 °C(Predicted)
• PKA: 5.84±0.36(Predicted)
• PSA: 24.92000
• Density: 1.470±0.06 g/cm3(Predicted)
• LogP: 3.52920

Purity/Quality:

99% ^*data from raw suppliers

3-BROMO-4-BENZYLAMINOPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-4-BENZYLAMINOPYRIDINE

There total 3 articles about 3-BROMO-4-BENZYLAMINOPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

3-bromopyridin-4-amine (13534-98-0) + benzyl bromide (100-39-0) → N-benzyl-3-bromopyridin-4-amine (100953-53-5)

Guidance literature:

3-bromopyridin-4-amine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 3h;

Reference yield:

3-Bromo-4-nitropyridine N-oxide (1678-49-5) → N-benzyl-3-bromopyridin-4-amine (100953-53-5)

Guidance literature:

Multi-step reaction with 2 steps

1: iron-powder; acetic acid

2: KOH; xylene

With potassium hydroxide; iron; acetic acid; xylene;

DOI:10.1021/jo01089a616

Reference yield:

3-bromopyridin-4-amine (13534-98-0) + benzyl alcohol (100-51-6,185532-71-2) → N-benzyl-3-bromopyridin-4-amine (100953-53-5)

Guidance literature:

With potassium hydroxide; xylene;

DOI:10.1021/jo01089a616

upstream raw materials:

3-bromopyridin-4-amine

benzyl alcohol

3-Bromo-4-nitropyridine N-oxide

benzyl bromide