4-Benzoyl-4-phenylbutyric acid

Base Information

• Chemical Name: 4-Benzoyl-4-phenylbutyric acid
• CAS No.: 4258-41-7
• Molecular Formula: C17H16O3
• Molecular Weight: 268.312
• Mol file: 4258-41-7.mol

Synonyms:4-Benzoyl-4-phenylbutyric acid

Chemical Property of 4-Benzoyl-4-phenylbutyric acid

Chemical Property:

• Melting Point: 133-134 °C
• Boiling Point: 457.6±33.0 °C(Predicted)
• PKA: 4.54±0.10(Predicted)
• PSA: 54.37000
• Density: 1.184±0.06 g/cm3(Predicted)
• LogP: 3.51790

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Benzoyl-4-phenylbutyric acid

There total 11 articles about 4-Benzoyl-4-phenylbutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

ethyl 5-oxo-4,5-diphenylpentanoate → 5-oxo-4,5-diphenylpentanoic acid (4258-41-7)

Guidance literature:

With sodium hydroxide; In water; at 60 ℃; for 1h;

DOI:10.1016/j.tet.2021.132034

Reference yield:

methyl 5-oxo-4,5-diphenylpentanoate (4258-42-8) → 5-oxo-4,5-diphenylpentanoic acid (4258-41-7)

Guidance literature:

With sodium hydroxide; In methanol; Heating;

Reference yield:

phenyl benzyl ketone (451-40-1) → 5-oxo-4,5-diphenylpentanoic acid (4258-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium t-butanolate / tetrahydrofuran / 2 h / 0 °C

2: sodium hydroxide; water / tetrahydrofuran / 2 h

With water; sodium hydroxide; sodium t-butanolate; In tetrahydrofuran;

DOI:10.1021/acs.orglett.9b01893

upstream raw materials:

phenyl benzyl ketone

acrolein

methyl 5-oxo-4,5-diphenylpentanoate

4-Hydroxy-5-oxo-4,5-diphenyl-pentansaeure

Downstream raw materials:

methyl 5-oxo-4,5-diphenylpentanoate

5,6-diphenyl-tetrahydro-pyran-2-one

5-hydroxy-4,5-diphenyl-valeric acid

γ-benzoyl-γ-phenyl-γ-butyrolactone

Refernces

• 1、 Dagenais, Robin,Lussier, Tommy,Legault, Claude Y.. "Iodine(III)-Mediated Contraction of 3,4-Dihydropyranones: Access to Polysubstituted γ-Butyrolactones". supporting information. p. 5290 - 5294. Retrieved 2019/09/03.