Technology Process of 3-Acetyl-1H-indole-4-carboxylic acid methyl ester
There total 2 articles about 3-Acetyl-1H-indole-4-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 1H-indole-4-carboxylate;
With
diethylaluminium chloride;
In
dichloromethane;
for 0.5h;
Inert atmosphere;
Cooling with ice;
acetyl chloride;
In
dichloromethane;
for 2h;
Inert atmosphere;
Cooling with ice;
- Guidance literature:
-
methyl 1H-indole-4-carboxylate;
With
tin(IV) chloride;
In
dichloromethane;
at 0 - 20 ℃;
for 0.5h;
Inert atmosphere;
acetic anhydride;
With
nitromethane;
In
dichloromethane;
at 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/acs.joc.9b03018
