1,2-Methylenedioxy-3-fluorobenzene

Base Information

• Chemical Name: 1,2-Methylenedioxy-3-fluorobenzene
• CAS No.: 943830-74-8
• Molecular Formula: C7H5FO2
• Molecular Weight: 140.114
• Hs Code.: 2932990090
• Mol file: 943830-74-8.mol

Synonyms:1,2-Methylenedioxy-3-fluorobenzene;3-Fluro-1,2-methylenedioxybenzene;4-Fluorobenzo[d][1,3]dioxole

Chemical Property of 1,2-Methylenedioxy-3-fluorobenzene

Chemical Property:

• PSA: 18.46000
• LogP: 1.55440
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

3-Fluro-1,2-methylenedioxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-Methylenedioxy-3-fluorobenzene

There total 1 articles about 1,2-Methylenedioxy-3-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-fluorocatechol (363-52-0) + 1,1-dibromomethane (74-95-3) → 4-fluorobenzo[1,3]dioxolane (943830-74-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 2h;

Reference yield: 47.0%

4-fluorobenzo[1,3]dioxolane (943830-74-8) + N,N-dimethyl-3-hydroxy-3-phenylpropylamine (5554-64-3) + oxalic acid (144-62-7,97993-78-7) → 3-[(benzo[d][1,3]dioxolan-4-yl)oxy]-N,N-dimethyl-3-phenylpropylamine oxalate

Guidance literature:

4-fluorobenzo[1,3]dioxolane; N,N-dimethyl-3-hydroxy-3-phenylpropylamine; With potassium hydroxide; In dimethyl sulfoxide; at 85 ℃; for 4h;

oxalic acid;

Reference yield:

4-fluorobenzo[1,3]dioxolane (943830-74-8) + N,N-dimethyl-3-hydroxy-3-phenylpropylamine (5554-64-3) → 3-[(benzo[d][1,3]dioxolan-4-yl)oxy]-N,N-dimethyl-3-phenylpropylamine

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 85 ℃; for 4h;

upstream raw materials:

3-fluorocatechol

1,1-dibromomethane

Downstream raw materials:

2-fluoro-3,4-methylenedioxyphenylboronic acid

Refernces

• 1、 -. "Deuterated optical isomer and medical application thereof". Paragraph 0010; 0013; 0014. . Retrieved 2019/01/08.
• 2、 -. "2-(POLY-SUBSTITUTED ARYL)-6-AMINO-5-HALO-4-PYRIMIDINECARBOXYLIC ACIDS AND THEIR USE AS HERBICIDES". Page/Page column 31. . Retrieved 2008/06/13.