2-Fluoro-3,4-methylenedioxyphenylboronic acid

Base Information

• Chemical Name: 2-Fluoro-3,4-methylenedioxyphenylboronic acid
• CAS No.: 943830-75-9
• Molecular Formula: C₇H₆BFO₄
• Molecular Weight: 183.932
• Hs Code.: 2932990090
• Mol file: 943830-75-9.mol

Synonyms:2-Fluoro-3,4-methylenedioxyphenylboronic acid;4-Fluorobenzo[d][1,3]dioxol-5-ylboronic acid

Chemical Property of 2-Fluoro-3,4-methylenedioxyphenylboronic acid

Chemical Property:

• PSA: 58.92000
• LogP: -0.76580
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-3,4-methylenedioxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Fluoro-3,4-methylenedioxyphenylboronic acid is used in the synthetic preparation of potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk).

Technology Process of 2-Fluoro-3,4-methylenedioxyphenylboronic acid

There total 1 articles about 2-Fluoro-3,4-methylenedioxyphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluorobenzo[1,3]dioxolane (943830-74-8) + Trimethyl borate (121-43-7,63156-11-6) → 2-fluoro-3,4-methylenedioxyphenylboronic acid (943830-75-9)

Guidance literature:

4-fluorobenzo[1,3]dioxolane; With n-butyllithium; In tetrahydrofuran; at -65 - -35 ℃; for 1h;

Trimethyl borate; In tetrahydrofuran; at -65 - 20 ℃;

With hydrogenchloride; water; In tetrahydrofuran; for 0.25h;

upstream raw materials:

4-fluorobenzo[1,3]dioxolane

Trimethyl borate

Refernces