2-BROMO-4'-CHLORO-5-METHOXYBENZOPHENONE

Base Information

• Chemical Name: 2-BROMO-4'-CHLORO-5-METHOXYBENZOPHENONE
• CAS No.: 746651-89-8
• Molecular Formula: C14H10BrClO2
• Molecular Weight: 325.589
• Hs Code.: 2914700090
• Mol file: 746651-89-8.mol

Synonyms:2-BROMO-4'-CHLORO-5-METHOXYBENZOPHENONE

Chemical Property of 2-BROMO-4'-CHLORO-5-METHOXYBENZOPHENONE

Chemical Property:

• Vapor Pressure: 1.33E-07mmHg at 25°C
• Boiling Point: 430.1°C at 760 mmHg
• Flash Point: 213.9°C
• PSA: 26.30000
• Density: 1.482g/cm³
• LogP: 4.34210

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-4'-chloro-5-methoxybenzophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-BROMO-4'-CHLORO-5-METHOXYBENZOPHENONE

There total 4 articles about 2-BROMO-4'-CHLORO-5-METHOXYBENZOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-bromo-α-(4-chlorophenyl)-5-methoxybenzenemethanol (1173238-24-8) → (2-bromo-5-methoxyphenyl)(4-chlorophenyl)methanone (746651-89-8)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.bmc.2020.115601

Reference yield:

(4-chlorphenyl)magnesium bromide (873-77-8) + 2-bromo-N,5-dimethoxy-N-methylbenzamide (374803-67-5) → (2-bromo-5-methoxyphenyl)(4-chlorophenyl)methanone (746651-89-8) + (4-chlorophenyl)(3-methoxyphenyl)methanone (32363-45-4)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

Reference yield:

(4-chlorphenyl)magnesium bromide (873-77-8) → (2-bromo-5-methoxyphenyl)(4-chlorophenyl)methanone (746651-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; diethyl ether / 2 h / 0 °C / Inert atmosphere

2: pyridinium chlorochromate / dichloromethane / 1.5 h / Inert atmosphere

With pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; dichloromethane;

upstream raw materials:

2-bromo-α-(4-chlorophenyl)-5-methoxybenzenemethanol

(4-chlorphenyl)magnesium bromide

2-bromo-N,5-dimethoxy-N-methylbenzamide

2-bromo-5-methoxy-benzaldehyde

Downstream raw materials:

1-bromo-2-[1-(4-chlorophenyl)ethenyl]-4-methoxybenzene

Refernces

• 1、 -. "TRICYCLIC FUSED DERIVATIVES OF 1-(CYCLO)ALKYL PYRIDIN-2-ONE USEFUL FOR THE TREATMENT OF CANCER". Paragraph 0187. . Retrieved 2018/10/21.
• 2、 Fukamachi, Shuhei,Konishi, Hisatoshi,Kobayashi, Kazuhiro. "Synthesis of 2-benzothiophene-1(3H)-thione and isothiochromene-1-thione derivatives by iodine-mediated cyclization of lithium 2-(vinyl)dithiobenzoate derivatives". experimental part. p. 169 - 176. Retrieved 2009/05/07.