Furo[2,3-b]pyridine-2-carboxaMide, 3-[(3-Methoxybenzoyl)aMino]-

Base Information

• Chemical Name: Furo[2,3-b]pyridine-2-carboxaMide, 3-[(3-Methoxybenzoyl)aMino]-
• CAS No.: 371944-46-6
• Molecular Formula: C16H13N3O4
• Molecular Weight: 311.297
• Hs Code.: 2934999090
• Mol file: 371944-46-6.mol

Synonyms:Furo[2,3-b]pyridine-2-carboxaMide, 3-[(3-Methoxybenzoyl)aMino]-

Chemical Property of Furo[2,3-b]pyridine-2-carboxaMide, 3-[(3-Methoxybenzoyl)aMino]-

Chemical Property:

• PSA: 110.94000
• LogP: 3.27190
• Storage Temp.: 2-8°C

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

3-(3-Methoxybenzamido)furo[2,3-b]pyridine-2-carboxamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Furo[2,3-b]pyridine-2-carboxaMide, 3-[(3-Methoxybenzoyl)aMino]-

There total 6 articles about Furo[2,3-b]pyridine-2-carboxaMide, 3-[(3-Methoxybenzoyl)aMino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

ethyl 3-(3-methoxybenzamido)furo[2,3-b]pyridine-2-carboxylate (371943-69-0) → 3-(3-methoxybenzamido)furo[2,3-b]pyridine-2-carboxamide (371944-46-6)

Guidance literature:

With ammonia; In methanol; water; at 20 ℃; for 12h;

DOI:10.1016/j.bmcl.2020.127258

Reference yield:

3-amino-furo[2,3-b]pyridine-2-carboxylic acid ethyl ester (371945-06-1) → 3-(3-methoxybenzamido)furo[2,3-b]pyridine-2-carboxamide (371944-46-6)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. NaOH / ethanol

2: SOCl₂ / Heating

3: aq. NH₃ / tetrahydrofuran

With ammonium hydroxide; sodium hydroxide; thionyl chloride; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2007.02.032

Reference yield:

C16H11ClN2O4 → 3-(3-methoxybenzamido)furo[2,3-b]pyridine-2-carboxamide (371944-46-6)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2007.02.032

upstream raw materials:

3-amino-furo[2,3-b]pyridine-2-carboxylic acid ethyl ester

ethyl 3-(3-methoxybenzamido)furo[2,3-b]pyridine-2-carboxylate

C₁₆H₁₂N₂O₅

2-chloro-3-pyridinecarbonitrile

Downstream raw materials:

2-(3-methoxyphenyl)pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-4(3H)-one

3-(4-oxo-3,4-dihydropyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl acetate

3-(4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol

C₂₃H₂₂N₄O₅

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