STARBURST(R) (PAMAM) DENDRIMER, GENERATION 1

Base Information

• Chemical Name: STARBURST(R) (PAMAM) DENDRIMER, GENERATION 1
• CAS No.: 142986-44-5
• Molecular Formula: C62H128 N26 O12
• Molecular Weight: 1429.87
• Mol file: 142986-44-5.mol

Synonyms:4,7,11,14,18,21-Hexaazatetracosanediamide,N,N'-bis(2-aminoethyl)-4,21-bis[3-[(2-aminoethyl)amino]-3-oxopropyl]-11,14-bis[3-[[2-[bis[3-[(2-aminoethyl)amino]-3-oxopropyl]amino]ethyl]amino]-3-oxopropyl]-8,17-dioxo-(9CI); PAMAM G 1; PAMAM dendrimer (G-1); Starburst 1st Generation

Chemical Property of STARBURST(R) (PAMAM) DENDRIMER, GENERATION 1

Chemical Property:

• Refractive Index: n20/D 1.362
• Boiling Point: 64.7 °C
• Flash Point: 52 °F
• PSA: 576.80000
• Density: 0.82 g/mL at 25 °C
• LogP: -1.16320
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

PAMAM dendrimer, ethylenediamine core, generation 1.0 solution 20 wt. % in methanol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25-36/37/38
• Safety Statements: 7-16-23-45-36/37-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of STARBURST(R) (PAMAM) DENDRIMER, GENERATION 1

There total 1 articles about STARBURST(R) (PAMAM) DENDRIMER, GENERATION 1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethylenediamine (107-15-3,85404-18-8) + PAMAM G0.5 (223709-11-3) → PAMAM G1 (142986-44-5)

Guidance literature:

In methanol; at 19.84 ℃; for 12.75h; Microwave irradiation;

DOI:10.1002/ejoc.201101717

Reference yield: 57.0%

2-(4-(prop-2-yn-1-yloxy)phenyl)acetic acid + PAMAM G1 (142986-44-5) → C150H192N26O28

Guidance literature:

2-(4-(prop-2-ynyloxy)phenyl)acetic acid; With 1-hydroxybenzotriazole hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.333333h;

PAMAM G₁; In N,N-dimethyl-formamide; at 35 ℃; for 120h;

DOI:10.1039/d0ra02574g

Reference yield: 39.0%

benzaldehyde (100-52-7) + PAMAM G1 (142986-44-5) → C118H160N26O12

Guidance literature:

With sodium sulfate; In methanol; at 60 ℃; for 12h;

DOI:10.1021/ja048219r

upstream raw materials:

ethylenediamine

PAMAM G_0.5

Refernces

• 1、 Zainul Abid,Jackeray, Richa,Jain, Swati,Chattopadhyay, Sruti,Asif,Singh, Harpal. "Antimicrobial efficacy of synthesized quaternary ammonium polyamidoamine dendrimers and dendritic polymer network". . p. 998 - 1007. Retrieved 2016.
• 2、 Ma, Minglu,Cheng, Yiyun,Xu, Zhenhua,Xu, Peng,Qu, Haiou,Fang, Yujie,Xu, Tongwen,Wen, Longping. "Evaluation of polyamidoamine (PAMAM) dendrimers as drug carriers of anti-bacterial drugs using sulfamethoxazole (SMZ) as a model drug". . p. 93 - 98. Retrieved 2007.
• 3、 Kavas,Durmus,Tanriverdi,?enel,Sozeri,Baykal. "Fabrication and characterization of dendrimer-encapsulated monometallic Co nanoparticles". . p. 5341 - 5348. Retrieved 2011.
• 4、 Beezer,King,Martin,Mitchel,Twyman,Wain. "Dendrimers as potential drug carriers; encapsulation of acidic hydrophobes within water soluble PAMAM derivatives". . p. 3873 - 3880. Retrieved 2003.
• 5、 Dodangeh, Mohammad,Grabchev, Ivo,Gharanjig, Kamaladin,Staneva, Desislava,Tang, Ren-Cheng,Sheridan, Matthew. "Modified PAMAM dendrimers as a matrix for the photostabilization of curcumin". . p. 17112 - 17121. Retrieved 2020.