2-hydrazinyl-5-[(4-methylphenyl)sulfonyl]-5H-Pyrrolo[2,3-b]pyrazine

Base Information

Chemical Name:2-hydrazinyl-5-[(4-methylphenyl)sulfonyl]-5H-Pyrrolo[2,3-b]pyrazine
CAS No.:1201186-57-3
Molecular Formula:C₁₃H₁₃N₅O₂S
Molecular Weight:303.345
Hs Code.:
Mol file:1201186-57-3.mol

Synonyms:2-hydrazinyl-5-[(4-methylphenyl)sulfonyl]-5H-Pyrrolo[2,3-b]pyrazine

Suppliers and Price of 2-hydrazinyl-5-[(4-methylphenyl)sulfonyl]-5H-Pyrrolo[2,3-b]pyrazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-hydrazinyl-5-[(4-methylphenyl)sulfonyl]-5H-Pyrrolo[2,3-b]pyrazine

Chemical Property:

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Technology Process of 2-hydrazinyl-5-[(4-methylphenyl)sulfonyl]-5H-Pyrrolo[2,3-b]pyrazine

There total 4 articles about 2-hydrazinyl-5-[(4-methylphenyl)sulfonyl]-5H-Pyrrolo[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1421338-19-3
C₂₃H₂₉N₅O₆S

: 1201186-57-3
2-hydrazinyl-5-tosyl-5H-pyrrolo[2,3-b]pyrazine

Guidance literature:: C₂₃H₂₉N₅O₆S; With phosphoric acid; In tetrahydrofuran; n-heptane; at 70 ℃; for 2h;

With potassium carbonate; In water; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2012.11.108

Reference yield:

: 870-46-2
t-butoxycarbonylhydrazine

: 1201186-54-0
2-bromo-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine

: 1201186-57-3
2-hydrazinyl-5-tosyl-5H-pyrrolo[2,3-b]pyrazine

Guidance literature:: t-butoxycarbonylhydrazine; 2-bromo-5-(4-methylbenzenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine; With sodium t-butanolate; tert-butyl XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 0.833333h;

With hydrogenchloride; In 1,4-dioxane; at 60 ℃; for 1h;

With sodium hydrogencarbonate; In water; for 1h;

Reference yield:

: 875781-41-2
5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine

: 1201186-57-3
2-hydrazinyl-5-tosyl-5H-pyrrolo[2,3-b]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

2.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium carbonate / 1,4-dioxane; tert-Amyl alcohol / 2 h / 95 °C

3.1: phosphoric acid / tetrahydrofuran; n-heptane / 2 h / 70 °C

3.2: 1 h / 20 °C

With phosphoric acid; palladium diacetate; sodium hydride; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; tert-Amyl alcohol; n-heptane; N,N-dimethyl-formamide; 2.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2012.11.108