Dabigatran Impurity 9

Base Information

Chemical Name:Dabigatran Impurity 9
CAS No.:1408238-41-4
Molecular Formula:C19H21N5O2
Molecular Weight:351.408
Hs Code.:
Mol file:1408238-41-4.mol

Synonyms:Dabigatran Impurity 9;1H-Benzimidazole-5-carboxylic acid, 2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-, ethyl ester;ethyl 2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-1H-benzo[d]imidazole-5-carboxylate

Suppliers and Price of Dabigatran Impurity 9

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 10 raw suppliers

Chemical Property of Dabigatran Impurity 9

Chemical Property:

PSA：106.02000
LogP:3.51920
Solubility.:Methanol; Ethanol

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Des-(3-(Pyridin-2-ylamino)propanoate) Dabigatran Ethyl Ester is an intermediate in the synthesis of 2-[[[4-[(Z)-Amino[[(hexyloxy)carbonyl]imino]methyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazole-5-carboxylic Acid (A611088), a degradation product of Dabigatran (D100090). which is a drug that is a nonpeptide, direct thrombin inhibitor and an antithrombotic.

Technology Process of Dabigatran Impurity 9

There total 6 articles about Dabigatran Impurity 9 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1117893-66-9
ethyl 2-(((4-cyanophenyl)amino)methyl)-1-methyl-1H-benzo[d]imidazole-5-carboxylate

: 1408238-41-4
ethyl 2-{[(4-{carbamimidoyl}phenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-carboxylate

Guidance literature:: ethyl 2-(((4-cyanophenyl)amino)methyl)-1-methyl-1H-benzo[d]imidazole-5-carboxylate; With hydrogenchloride; In ethanol; at 20 ℃; for 24h;

With ammonium hydroxide; In ethanol; at 10 - 20 ℃;

Reference yield: 86.0%

: 64-17-5
ethanol

: ethyl 3-(2-(((4-(ethoxy(imino)methyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propionate

: 1408238-41-4
ethyl 2-{[(4-{carbamimidoyl}phenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-carboxylate

: 429658-95-7
3-({2-[(4-carbamimidoylphenylamino)methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}pyridin-2-yl-amino)propionic acid ethyl ester

Guidance literature:: With ammonium carbonate; at 0 - 25 ℃; for 12h; Inert atmosphere;

Reference yield:

: 211915-84-3
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

: 1408238-41-4
ethyl 2-{[(4-{carbamimidoyl}phenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-carboxylate

: 429658-95-7
3-({2-[(4-carbamimidoylphenylamino)methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}pyridin-2-yl-amino)propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 14 h / 0 - 30 °C / Inert atmosphere

2: ammonium carbonate / 12 h / 0 - 25 °C / Inert atmosphere

With hydrogenchloride; ammonium carbonate;