Des-(N-2-pyridyl-β-alanine Ethyl Ester) Dabigatran Etexilate 5-Ethyl Carboxylate (Dabigatran IMpurity)

Base Information

Chemical Name:Des-(N-2-pyridyl-β-alanine Ethyl Ester) Dabigatran Etexilate 5-Ethyl Carboxylate (Dabigatran IMpurity)
CAS No.:1408238-36-7
Molecular Formula:C26H33N5O4
Molecular Weight:479.579
Hs Code.:
Mol file:1408238-36-7.mol

Synonyms:Des-(N-2-pyridyl-β-alanine Ethyl Ester) Dabigatran Etexilate 5-Ethyl Carboxylate (Dabigatran IMpurity);Dabigatran Etexilate Mesylate impurity H;ethyl (E)-2-(((4-(N'- ((hexyloxy)carbonyl)carbamimidoyl)p henyl)amino)methyl)-1-methyl-1Hbenzo[ d]imidazole-5-carboxylate

Suppliers and Price of Des-(N-2-pyridyl-β-alanine Ethyl Ester) Dabigatran Etexilate 5-Ethyl Carboxylate (Dabigatran IMpurity)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Des-(N-2-pyridyl-β-alanineEthylEster)DabigatranEtexilate5-EthylCarboxylate(DabigatranImpurity)
5mg
$ 160.00

TRC
Des-(N-2-pyridyl-β-alanineEthylEster)DabigatranEtexilate5-EthylCarboxylate(DabigatranImpurity)
50mg
$ 1260.00

ChemScene
Ethyl2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-1H-benzo[d]imidazole-5-carboxylate ≥97.0%
100mg
$ 171.00

Total 16 raw suppliers

Chemical Property of Des-(N-2-pyridyl-β-alanine Ethyl Ester) Dabigatran Etexilate 5-Ethyl Carboxylate (Dabigatran IMpurity)

Chemical Property:

PKA:9.88±0.46(Predicted)
PSA：118.33000
Density:1.22±0.1 g/cm3(Predicted)
LogP:5.55760
Storage Temp.:-20°C, Inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Des-(N-2-pyridyl-β-alanineEthylEster)DabigatranEtexilate5-EthylCarboxylate(DabigatranImpurity) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Des-(N-2-pyridyl-β-alanine ethyl ester) Dabigatran etexilate 5-ethyl carboxylate is a derivative of Dabigatran (D100090), an oral thrombin inhibitor used to prevent venous thromboembolism.

Technology Process of Des-(N-2-pyridyl-β-alanine Ethyl Ester) Dabigatran Etexilate 5-Ethyl Carboxylate (Dabigatran IMpurity)

There total 13 articles about Des-(N-2-pyridyl-β-alanine Ethyl Ester) Dabigatran Etexilate 5-Ethyl Carboxylate (Dabigatran IMpurity) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 6092-54-2
n-hexyl chloroformate

: 1408238-41-4
ethyl 2-{[(4-{carbamimidoyl}phenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-carboxylate

: 1408238-36-7
ethyl 2-[[4-[(n-hexyloxycarbonyl)aminoiminomethyl]phenylamino]methyl]-1-methyl-1H-benzimidazole-5-carboxylate

Guidance literature:: With sodium hydroxide; In water; acetone; at 10 - 25 ℃;

Reference yield: 74.3%

: 64-17-5
ethanol

: 6092-54-2
n-hexyl chloroformate

: ethyl 3-(2-(((4-(ethoxy(imino)methyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propionate

: 211915-06-9
dabigatran etexilate

: 1408238-36-7
ethyl 2-[[4-[(n-hexyloxycarbonyl)aminoiminomethyl]phenylamino]methyl]-1-methyl-1H-benzimidazole-5-carboxylate

Guidance literature:: ethanol; ethyl 3-(2-(((4-(ethoxy(imino)methyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propionate; With ammonium carbonate; at 0 - 25 ℃; for 12h; Inert atmosphere;

n-hexyl chloroformate; With potassium carbonate; In tetrahydrofuran; water; at 10 - 30 ℃; for 1h; Inert atmosphere;