2-Methyl-2,8-diazaspiro[4.5]decan-1-one

Base Information

Chemical Name:2-Methyl-2,8-diazaspiro[4.5]decan-1-one
CAS No.:546093-44-1
Molecular Formula:C₉H₁₆N₂O
Molecular Weight:168.239
Hs Code.:
DSSTox Substance ID:DTXSID201279448
ChEMBL ID:CHEMBL4571108
Mol file:546093-44-1.mol

Synonyms:2-Methyl-2,8-diazaspiro[4.5]decan-1-one;546093-44-1;2,8-Diazaspiro[4.5]decan-1-one, 2-methyl-;SCHEMBL345569;CHEMBL4571108;DTXSID201279448;MFCD16249889;AKOS024016049;SB42528;SY045162;CS-0090654;FT-0719062;D74956;EN300-154336

Suppliers and Price of 2-Methyl-2,8-diazaspiro[4.5]decan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-Methyl-2,8-diazaspiro[4.5]decan-1-one

Chemical Property:

PSA：32.34000
LogP:0.48500
XLogP3:-0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:168.126263138
Heavy Atom Count:12
Complexity:197

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1CCC2(C1=O)CCNCC2

Technology Process of 2-Methyl-2,8-diazaspiro[4.5]decan-1-one

There total 2 articles about 2-Methyl-2,8-diazaspiro[4.5]decan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1061683-09-7
tert-butyl 2-methyl-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate

: 546093-44-1
2-methyl-2,8-diazaspiro[4.5]decan-1-one

Guidance literature:: With formic acid; at 100 ℃; for 1h;

Reference yield:

: 268550-48-7
1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester

: 546093-44-1
2-methyl-2,8-diazaspiro[4.5]decan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 16 h / 0 - 25 °C

2.1: formic acid / 1 h / 100 °C

With formic acid; sodium hydride; In N,N-dimethyl-formamide; mineral oil;

Reference yield: 15.0%

: 546093-44-1
2-methyl-2,8-diazaspiro[4.5]decan-1-one

: 6-chloro-2-phenyl-N-(4-(trifluoromethoxy)pyridin-2-yl)pyrimidin-4-amine

: 2-methyl-8-(2-phenyl-6-((4-(trifluoromethoxy)pyridin-2-yl)amino)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 10h; Inert atmosphere; Heating;