1-Phenyl-2-(4-fluophenyl)benzimidazole

Base Information

• Chemical Name: 1-Phenyl-2-(4-fluophenyl)benzimidazole
• CAS No.: 2622-70-0
• Molecular Formula: C19H13FN2
• Molecular Weight: 288.324
• Mol file: 2622-70-0.mol

Synonyms:1-Phenyl-2-(4-fluophenyl)benzimidazole;2-(4-Fluorophenyl)-1-phenyl-1H-benzo[d]imidazole

Chemical Property of 1-Phenyl-2-(4-fluophenyl)benzimidazole

Chemical Property:

• Melting Point: 100-101 °C
• Boiling Point: 464.2±47.0 °C(Predicted)
• PKA: 3.98±0.10(Predicted)
• PSA: 17.82000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 4.83160

Purity/Quality:

95%-98% ^*data from raw suppliers

2-(4-Fluorophenyl)-1-phenyl-1H-benzo[d]imidazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Phenyl-2-(4-fluophenyl)benzimidazole

There total 4 articles about 1-Phenyl-2-(4-fluophenyl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-fluorobenzaldehyde (459-57-4) + N-phenyl-1,2-benzenediamine (534-85-0) → 2-(4-flluorophenyl)-1-phenyl-1H-benzo[d]imidazole (2622-70-0)

Guidance literature:

With ammonium acetate; cobalt(II) hydroxide; In ethanol; at 80 ℃; for 1h; Reagent/catalyst;

DOI:10.1039/c3pp50083g

Reference yield: 80.0%

4-fluorobenzoyl chloride (403-43-0) + N-phenyl-1,2-benzenediamine (534-85-0) → 2-(4-flluorophenyl)-1-phenyl-1H-benzo[d]imidazole (2622-70-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 6h;

Reference yield: 80.0%

para-fluorobenzylamine (140-75-0) + N-phenyl-1,2-benzenediamine (534-85-0) → 2-(4-flluorophenyl)-1-phenyl-1H-benzo[d]imidazole (2622-70-0)

Guidance literature:

With 1-(3-amino-2,4-dihydroxyphenyl)-1-ethanone; copper(ll) bromide; In methanol; at 45 ℃; for 24h;

DOI:10.1002/chem.201502487

upstream raw materials:

4-fluorobenzoyl chloride

N-phenyl-1,2-benzenediamine

4-fluorobenzaldehyde

para-fluorobenzylamine

Refernces

• 1、 Zhao, Jin-Hui,Hu, Yong-Xu,Dong, Yan,Xia, Xin,Chi, Hai-Jun,Xiao, Guo-Yong,Li, Xiao,Zhang, Dong-Yu. "Novel bluish green benzimidazole-based iridium(III) complexes for highly efficient phosphorescent organic light-emitting diodes". . p. 1973 - 1979. Retrieved 2017/03/09.
• 2、 Jayabharathi,Thanikachalam,Jayamoorthy. "Synthesis of some fluorescent benzimidazole derivatives using cobalt(ii) hydroxide as highly efficient catalyst-spectral and physico-chemical studies and ESIPT process". . p. 1761 - 1773. Retrieved 2013/10/08.