2,2-Dichloropropionic acid isopropyl ester

Base Information

• Chemical Name: 2,2-Dichloropropionic acid isopropyl ester
• CAS No.: 54587-48-3
• Molecular Formula: C6H10Cl2O2
• Molecular Weight: 185.05
• Mol file: 54587-48-3.mol

Synonyms:2,2-Dichloropropionic acid isopropyl ester

Chemical Property of 2,2-Dichloropropionic acid isopropyl ester

Chemical Property:

• PSA: 26.30000
• LogP: 2.13180

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Dichloropropionic acid isopropyl ester

There total 1 articles about 2,2-Dichloropropionic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl bromide (74-83-9) + isopropyl dichloroacetate (25006-60-4) → isopropyl 2,2-dichloropropanoate (54587-48-3)

Guidance literature:

Multistep reaction; (i) Et₂NH, Li, HMPT, benzene, (ii) /BRN= 1753505/, THF, (iii) /BRN= 1209223/;

DOI:10.1055/s-1975-23832

Reference yield: 68.0%

isopropyl 2,2-dichloropropanoate (54587-48-3) + 3-O-benzyl-1,2-O-isopropylidene-1,5-D-xylo-dialdofuranose (23558-05-6) → isopropyl (E)-3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene-6-C-methyl-α-D-xylo-hept-5-enofuranuronate (1310802-49-3)

Guidance literature:

With chromium dichloride; In tetrahydrofuran; at 75 ℃; for 3h; optical yield given as %de; stereoselective reaction; Inert atmosphere;

DOI:10.1021/jo200548g

Reference yield:

isopropyl 2,2-dichloropropanoate (54587-48-3) + benzyl bromide (100-39-0) → 2-Chloro-2-methyl-3-phenyl-propionic acid isopropyl ester (54587-35-8)

Guidance literature:

Multistep reaction; (i) MeMgBr, CuBr, THF, (ii) /BRN= 385801/;

DOI:10.1016/S0022-328X(00)88196-6

upstream raw materials:

methyl bromide

isopropyl dichloroacetate

Downstream raw materials:

2-Chloro-2-methyl-3-phenyl-propionic acid isopropyl ester

2-Chloro-3-hydroxy-2-methyl-3-phenyl-propionic acid isopropyl ester

isopropyl (E)-3-O-benzyl-5,6-dideoxy-1,2-O-isopropylidene-6-C-methyl-α-D-xylo-hept-5-enofuranuronate