25006-60-4

Usage

Uses

Used in Pharmaceutical Industry:
Isopropyl dichloroacetate is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its reactivity allows for the creation of a diverse range of drug derivatives, contributing to the development of new medications and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, isopropyl dichloroacetate is employed as a precursor in the production of various agrochemicals. Its role in the synthesis of these compounds aids in the development of effective solutions for agricultural applications, such as pesticides and herbicides.
Used in Organic Synthesis:
Isopropyl dichloroacetate is used as a versatile building block in organic synthesis for the creation of a wide array of organic compounds. Its unique properties and reactivity make it an indispensable component in the synthesis of complex organic molecules for various applications.
Used in Research Applications:
In research settings, isopropyl dichloroacetate is employed as a valuable reagent for studying chemical reactions and exploring new synthetic pathways. Its unique characteristics and reactivity provide researchers with a powerful tool for advancing the understanding of chemical processes and developing innovative synthetic methods.
Used in Industrial Applications:
Isopropyl dichloroacetate is widely used in industrial applications due to its ability to facilitate the production of a variety of chemical products. Its role as an intermediate in the synthesis of numerous compounds makes it a vital component in the manufacturing processes of various industries.

InChI:InChI=1/C5H8Cl2O2/c1-3(2)9-5(8)4(6)7/h3-4H,1-2H3

Upstream product

• 79-43-6 dichloro-acetic acid 
• 187737-37-7 propene 
• 67-63-0 isopropyl alcohol 
• 79-36-7 dichloroacethyl chloride 
• 7637-07-2 boron trifluoride 
• 1768-31-6 pentachloroacetone 

Downstream Products

• 54587-48-3 isopropyl 2,2-dichloropropanoate 
• 21806-25-7 (1-Chlor-cyclohexyl)-glyoxylsaeure-isopropylester 
• 56884-02-7 Isopropyl-2,2-dichlor-3-methylbutanoat 
• 29804-84-0 2-chloro-3,3-dimethyl-oxiranecarboxylic acid isopropyl ester 
• 881011-56-9 3-(4-methoxy-phenyl)-3-(2-nitro-phenylsulfanyl)-2-oxo-propionic acid isopropyl ester 
• 58190-72-0 2-Cyclohexyl-2-methyl-butyric acid isopropyl ester 
• 54587-35-8 2-Chloro-2-methyl-3-phenyl-propionic acid isopropyl ester 
• 54587-37-0 2-Chloro-3-hydroxy-2-methyl-3-phenyl-propionic acid isopropyl ester 

Relevant academic research and scientific papers

A simple synthesis of 2-keto-3-deoxy-D-erythro-hexonic acid isopropyl ester, a key sugar for the bacterial population living under metallic stress

2-Keto-3-deoxy-D-erythro-hexonic acid (KDG) is the key intermediate metabolite of the Entner Doudoroff (ED) pathway. A simple, efficient and stereoselective synthesis of KDG isopropyl ester is described in five steps from 2,3-O-isopropylidene-D-threitol with an overall yield of 47%. KDG isopropyl ester is studied as an attractive marker of a functional Entner Doudoroff pathway. KDG isopropyl ester is used to promote growth of ammonium producing bacterial strains, showing interesting features in the remediation of heavy-metal polluted soils.

Synthesis and evaluation of dual site inhibitors of 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase

3-Deoxy-d-arabino-heptulosonate 7-phosphate (DAH7P) synthase catalyses the first step of the shikimate pathway for the biosynthesis of aromatic compounds. Enzymes of this pathway have been identified as potential targets for drug design. The reaction catalysed by DAH7P synthase is an aldol condensation between phosphoenolpyruvate (PEP) and d-erythrose 4-phosphate (E4P). In this study inhibitors of DAH7P synthase were prepared which were designed to fit into the binding sites of both PEP and E4P substrates simultaneously. Inhibitors, known to target the PEP binding site, were extended using a C4 linker to include an appropriately placed phosphate group in order to access the phosphate-binding site of E4P. A small increase in inhibition was observed with this modification, and the inhibition results have been rationalised by induced-fit docking.

Process for preparing 3-hydroxy 2-keto acids

A process has now been discovered by which an intermediate in preparation of antibiotics STR1 may be directly derived from the substrate STR2 by treatment with aqueous solutions of MHCO3 and MOH, wherein: R1, R2 and R3 are each independently alkyl, alkenyl, alkynyl, substituted alkyl, substituted alkenyl, substituted alkynyl, aryl, or substituted aryl; M is alkali metal (such as Na, Li, or K); and X is halogen.