1-(4-Chlorophenyl)-2-(hydroxyimino)ethanone

Base Information

• Chemical Name: 1-(4-Chlorophenyl)-2-(hydroxyimino)ethanone
• CAS No.: 3750-07-0
• Molecular Formula: C8H6ClNO2
• Molecular Weight: 183.594
• Hs Code.: 2928000090
• Mol file: 3750-07-0.mol

Synonyms:1-(4-Chlorophenyl)-2-(hydroxyimino)ethanone

Chemical Property of 1-(4-Chlorophenyl)-2-(hydroxyimino)ethanone

Chemical Property:

• Melting Point: 170 °C
• Boiling Point: 354.9±44.0 °C(Predicted)
• PKA: 8.14±0.10(Predicted)
• PSA: 49.66000
• Density: 1.29±0.1 g/cm3(Predicted)
• LogP: 1.98270

Purity/Quality:

(4-Chloro-phenyl)-oxo-acetaldehydeoxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-Chlorophenyl)-2-(hydroxyimino)ethanone

There total 9 articles about 1-(4-Chlorophenyl)-2-(hydroxyimino)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

para-chloroacetophenone (99-91-2) → 2-(4-chlorophenyl)-2-oxoacetaldehyde oxime (3750-07-0)

Guidance literature:

With chloro-trimethyl-silane; isopentyl nitrite; In dichloromethane; at -20 ℃;

DOI:10.1016/S0040-4039(03)00248-X

Reference yield: 54.0%

para-chloroacetophenone (99-91-2) → (E)-2-(4-chlorophenyl)-2-oxoacetaldehyde oxime (3750-07-0)

Guidance literature:

para-chloroacetophenone; With sodium; In ethanol; at 20 ℃; for 0.583333h; Inert atmosphere;

With isopentyl nitrite; In ethanol; at 0 ℃; for 73h; Cooling;

With acetic acid; In water;

DOI:10.1021/acs.joc.5b01380

Reference yield:

para-chloroacetophenone (99-91-2) → 2-(4-chlorophenyl)-2-oxoacetaldehyde oxime (3750-07-0) + para-chlorobenzoic acid (74-11-3)

Guidance literature:

With nitrosylchloride;

upstream raw materials:

n-Butyl nitrite

para-chloroacetophenone

sodium ethanolate

isopentyl nitrite

Downstream raw materials:

(4-chloro-phenyl)-hydroxyimino-acetaldehyde oxime

anti-(4-chlorophenyl)glyoxime

para-chlorobenzoic acid

3-(4-chloro-phenyl)-1-(2-hydroxy-ethyl)-quinoxalinium; chloride