(2R)-4-Bromo-2-[[(tert-butoxy)carbonyl]amino]butanoic acid tert-butyl ester

Base Information

Chemical Name:(2R)-4-Bromo-2-[[(tert-butoxy)carbonyl]amino]butanoic acid tert-butyl ester
CAS No.:123004-74-0
Molecular Formula:C13H24BrNO4
Molecular Weight:338.242
Hs Code.:
Mol file:123004-74-0.mol

Synonyms:(2R)-4-Bromo-2-[[(tert-butoxy)carbonyl]amino]butanoic acid tert-butyl ester;(R)-4-Bromo-2-[[(tert-butoxy)carbonyl]amino]butanoic acid tert-butyl ester

Suppliers and Price of (2R)-4-Bromo-2-[[(tert-butoxy)carbonyl]amino]butanoic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(R)-tert-Butyl4-bromo-2-((tert-butoxycarbonyl)amino)butanoate 97%
1g
$ 559.00

Total 7 raw suppliers

Chemical Property of (2R)-4-Bromo-2-[[(tert-butoxy)carbonyl]amino]butanoic acid tert-butyl ester

Chemical Property:

Boiling Point:390.3±37.0 °C(Predicted)
PKA:10.84±0.46(Predicted)
PSA：64.63000
Density:1.240
LogP:3.39730

Purity/Quality:

99%, ^*data from raw suppliers

(R)-tert-Butyl4-bromo-2-((tert-butoxycarbonyl)amino)butanoate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2R)-4-Bromo-2-[[(tert-butoxy)carbonyl]amino]butanoic acid tert-butyl ester

There total 2 articles about (2R)-4-Bromo-2-[[(tert-butoxy)carbonyl]amino]butanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 110207-49-3
tert-butyl D-N-(tert-butoxycarbonyl)homoserinate

: 123004-74-0
tert-butyl D-2-<(tert-butoxycarbonyl)amino>-4-bromobutyrate

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/ja00158a040

Reference yield:

: 77004-75-2
(3R)-4-tert-butoxy-3-[(tert-butoxycarbonyl)amino]-4-oxobutanoic acid

: 123004-74-0
tert-butyl D-2-<(tert-butoxycarbonyl)amino>-4-bromobutyrate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) triethylamine, ethyl chloroformate, 2.) sodium borohydride / 1.) THF, RT, 30 min, 2.) water, RT, 4 h

2: 91 percent / carbon tetrabromide, triphenylphosphine / CH₂Cl₂ / 2 h / Ambient temperature

With sodium tetrahydroborate; carbon tetrabromide; chloroformic acid ethyl ester; triethylamine; triphenylphosphine; In dichloromethane;
DOI:10.1021/ja00158a040

Reference yield: 46.0%

: 123004-74-0
tert-butyl D-2-<(tert-butoxycarbonyl)amino>-4-bromobutyrate

: 72594-86-6
1-benzyl 3-(tert-butyl) malonate

: 1407507-33-8
di-tert-butyl (5R)-2-(benzyloxycarbonyl)-5-[(tert-butoxycarbonyl)amino]hexane-dioate

Guidance literature:: 1-benzyl 3-(tert-butyl) malonate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h;

tert-butyl D-2-<(tert-butoxycarbonyl)amino>-4-bromobutyrate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 60h;