(R)-4-[4-((R)-Benzyloxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester

Base Information

Chemical Name:(R)-4-[4-((R)-Benzyloxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester
CAS No.:123004-76-2
Molecular Formula:C₄₄H₅₆N₄O₁₂
Molecular Weight:832.948
Hs Code.:

(R)-4-[4-((R)-Benzyloxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester

Synonyms:(R)-4-[4-((R)-Benzyloxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester

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Chemical Property of (R)-4-[4-((R)-Benzyloxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester

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Technology Process of (R)-4-[4-((R)-Benzyloxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester

There total 8 articles about (R)-4-[4-((R)-Benzyloxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 123004-73-9
(-)-tert-butyl 3-aminonocardicinate hydrochloride

: 123004-75-1
D-N-(benzyloxycarbonyl)-2-<4--3-(tert-butoxycarbonyl)propoxy>phenyl>glycine

: 123004-76-2
(R)-4-[4-((R)-Benzyloxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester

Guidance literature:: With 2,6-dimethylpyridine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1.) 0 deg C, 30 min, 2.) RT, 1.5 h;
DOI:10.1021/ja00158a040

Reference yield:

: 111216-46-7
tert-butyl N-(4,5-diphenyl-4-oxazolin-2-onyl)-L-seryl-D-glycinate

: 123004-76-2
(R)-4-[4-((R)-Benzyloxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / triethyl phosphite, diethyl azodicarboxylate / tetrahydrofuran / 4.5 h

2: 89 percent / 1N HCl / Pd/C / ethyl acetate; methanol; acetic acid / 44 h / 2068.6 Torr

3: 88 percent / 2,6-lutidine, 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) RT, 1.5 h

With 2,6-dimethylpyridine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; diethylazodicarboxylate; triethyl phosphite; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; ethyl acetate;
DOI:10.1021/ja00158a040

Reference yield:

: 110207-46-0
(-)-3-N-(4,5-diphenyl-4-oxazolin-2-onyl)aminocardicinic acid tert-butyl ester

: 123004-76-2
(R)-4-[4-((R)-Benzyloxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 1N HCl / Pd/C / ethyl acetate; methanol; acetic acid / 44 h / 2068.6 Torr

2: 88 percent / 2,6-lutidine, 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) RT, 1.5 h

With 2,6-dimethylpyridine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; ethyl acetate;
DOI:10.1021/ja00158a040