Benzothiazole, 5-(diethylamino)-2-methyl- (7CI)

Base Information

• Chemical Name: Benzothiazole, 5-(diethylamino)-2-methyl- (7CI)
• CAS No.: 91559-24-9
• Molecular Formula: C12H16N2S
• Molecular Weight: 220.338
• Mol file: 91559-24-9.mol

Synonyms:Benzothiazole, 5-(diethylamino)-2-methyl- (7CI)

Chemical Property of Benzothiazole, 5-(diethylamino)-2-methyl- (7CI)

Chemical Property:

• Boiling Point: 333.7±15.0 °C (760 mmHg)
• PSA: 44.37000
• Density: 1.138±0.06 g/cm3 (20 °C, 760 mmHg)
• LogP: 3.45090

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzothiazole, 5-(diethylamino)-2-methyl- (7CI)

There total 3 articles about Benzothiazole, 5-(diethylamino)-2-methyl- (7CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl bromide (74-96-4) + 2-methyl-5-aminobenzothiazole (13382-43-9) → 5-diethylamino-2-methylbenzothiazole (91559-24-9)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 72h; Inert atmosphere; Schlenk technique;

DOI:10.1021/jacs.6b10410

Reference yield:

5-bromo-2-methylbenzothiazole (63837-11-6) + diethylamine (109-89-7) → 5-diethylamino-2-methylbenzothiazole (91559-24-9)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; DavePhos; In 1,4-dioxane; at 95 ℃; for 24h; Inert atmosphere; Glovebox;

Reference yield:

→ 5-diethylamino-2-methylbenzothiazole (91559-24-9)

Guidance literature:

With sodium sulfide; sodium hydroxide; Behandeln des Reaktionsprodukts mit Acetanhydrid;

upstream raw materials:

ethyl bromide

2-methyl-5-aminobenzothiazole

5-bromo-2-methylbenzothiazole

diethylamine

Refernces

• 1、 -. "COMPOUNDS FOR FLUORESCENCE SENSING OF DUPLEX FORMATION". Paragraph 0168; 0170-0173. . Retrieved 2020/08/30.