7-FLUORO-10-(4-FLUORO-PHENYL)-4-METHYL-9,10-DIHYDRO-4H-2-OXA-4,10-DIAZA-BENZO[F]AZULENE-1,3-DIONE

Base Information

• Chemical Name: 7-FLUORO-10-(4-FLUORO-PHENYL)-4-METHYL-9,10-DIHYDRO-4H-2-OXA-4,10-DIAZA-BENZO[F]AZULENE-1,3-DIONE
• CAS No.: 535920-90-2
• Molecular Formula: C₁₈H₁₂F₂N₂O₃
• Molecular Weight: 342.302
• Mol file: 535920-90-2.mol

Synonyms:7-FLUORO-10-(4-FLUORO-PHENYL)-4-METHYL-9,10-DIHYDRO-4H-2-OXA-4,10-DIAZA-BENZO[F]AZULENE-1,3-DIONE

Chemical Property of 7-FLUORO-10-(4-FLUORO-PHENYL)-4-METHYL-9,10-DIHYDRO-4H-2-OXA-4,10-DIAZA-BENZO[F]AZULENE-1,3-DIONE

Chemical Property:

Purity/Quality:

7-FLUORO-10-(4-FLUORO-PHENYL)-4-METHYL-9,10-DIHYDRO-4H-2-OXA-4,10-DIAZA-BENZO[F]AZULENE-1,3-DIONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-FLUORO-10-(4-FLUORO-PHENYL)-4-METHYL-9,10-DIHYDRO-4H-2-OXA-4,10-DIAZA-BENZO[F]AZULENE-1,3-DIONE

There total 2 articles about 7-FLUORO-10-(4-FLUORO-PHENYL)-4-METHYL-9,10-DIHYDRO-4H-2-OXA-4,10-DIAZA-BENZO[F]AZULENE-1,3-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

oxalyl dichloride (79-37-8) + N-(4-fluorophenyl)-N-methylformamide (142212-08-6) → 1,2-dichloro-N,N'-bis-(4-fluoro-phenyl)-N,N'-dimethyl-ethene-1,2-diamine + 7-fluoro-4-(4-fluorophenyl)-1-methylbenzo[f][1,4]-diazepine-2,3-dicarboxylic anhydride (535920-90-2)

Guidance literature:

oxalyl dichloride; N-(4-fluorophenyl)-N-methylformamide; at 0 ℃;

With N-ethyl-N,N-diisopropylamine; In xylene; at -78 - 20 ℃; for 3h;

With water; In xylene; at 50 ℃; for 9h;

DOI:10.1039/b307278a

Reference yield: 41.0%

oxalyl dichloride (79-37-8) + N-(4-fluorophenyl)-N-methylformamide (142212-08-6) → 7-fluoro-4-(4-fluorophenyl)-1-methylbenzo[f][1,4]-diazepine-2,3-dicarboxylic anhydride (535920-90-2)

Guidance literature:

oxalyl dichloride; N-(4-fluorophenyl)-N-methylformamide; at 0 ℃;

With N-ethyl-N,N-diisopropylamine; In xylene; at -78 ℃; for 0.5h;

With acetylenedicarboxylic acid diethyl ester; In xylene; at -78 - 50 ℃; for 5h;

DOI:10.1039/b210098c

upstream raw materials:

oxalyl dichloride

N-(4-fluorophenyl)-N-methylformamide