2,5-DIBROMO-4-NITROPYRIDINE 1-OXIDE

Base Information

• Chemical Name: 2,5-DIBROMO-4-NITROPYRIDINE 1-OXIDE
• CAS No.: 221241-25-4
• Molecular Formula: C5H2Br2N2O3
• Molecular Weight: 297.89
• Hs Code.: 2933399090
• Mol file: 221241-25-4.mol

Synonyms:2,5-DIBROMO-4-NITROPYRIDINE 1-OXIDE;2,4-Dibromo-4-nitropyridine-N-oxide

Chemical Property of 2,5-DIBROMO-4-NITROPYRIDINE 1-OXIDE

Chemical Property:

• Boiling Point: 423.5±40.0 °C(Predicted)
• PKA: -3.35±0.10(Predicted)
• PSA: 71.28000
• Density: 2.42±0.1 g/cm3(Predicted)
• LogP: 3.07150

Purity/Quality:

98% ^*data from raw suppliers

2,5-Dibromo-4-nitropyridin-1-ium-1-olate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-DIBROMO-4-NITROPYRIDINE 1-OXIDE

There total 2 articles about 2,5-DIBROMO-4-NITROPYRIDINE 1-OXIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2,5-dibromopyridine N-oxide (20734-22-9) → C5H2Br2N2O3 (221241-25-4)

Guidance literature:

With sulfuric acid; nitric acid; at 100 ℃; for 2h;

Reference yield:

2,5-dibromopyridine (624-28-2) → C5H2Br2N2O3 (221241-25-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid; dihydrogen peroxide / 5 h / 70 - 90 °C

2: nitric acid; sulfuric acid / 2 h / 20 - 100 °C

With sulfuric acid; dihydrogen peroxide; nitric acid; trifluoroacetic acid;

Reference yield: 82.0%

C5H2Br2N2O3 (221241-25-4) + 4-fluorophenylmagnesium chloride (130387-74-5) → C11H5Br2FN2O3 (1422047-30-0)

Guidance literature:

C₅H₂Br₂N₂O₃; 4-fluorophenylmagnesium chloride; In tetrahydrofuran; at -50 ℃;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1021/jo302511s

upstream raw materials:

2,5-dibromopyridine N-oxide

2,5-dibromopyridine

Downstream raw materials:

C₁₁H₅Br₂FN₂O₃

2,5-dibromo-4-nitropyridine

Refernces

• 1、 -. "ANTI-FIBROTIC PYRIDINONES". Paragraph 0832; 0834. . Retrieved 2014/04/17.