2-(MethoxyMethyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

Base Information

Chemical Name:2-(MethoxyMethyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS No.:1430401-34-5
Molecular Formula:C₁₃H₂₀BNO₃
Molecular Weight:249.118
Hs Code.:
Mol file:1430401-34-5.mol

Synonyms:2-(MethoxyMethyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

Suppliers and Price of 2-(MethoxyMethyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AOBChem
2-Methoxymethylpyridine-3-boronicacidpinacolester 95%
5g
$ 4470.00

AOBChem
2-Methoxymethylpyridine-3-boronicacidpinacolester 95%
1g
$ 1251.00

Total 3 raw suppliers

Chemical Property of 2-(MethoxyMethyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Methoxymethylpyridine-3-boronicacidpinacolester 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(MethoxyMethyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

There total 3 articles about 2-(MethoxyMethyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1000787-43-8
5-bromo-2-(methoxymethyl)pyridine

: 73183-34-3
bis(pinacol)diborane

: 1430401-34-5
2-(methoxymethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 85 ℃; for 4h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b00519

Reference yield:

: 23579-92-2
2-(methoxymethyl)pyridine

: 73183-34-3
bis(pinacol)diborane

: 1430401-34-5
2-(methoxymethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 2-(methoxymethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Guidance literature:: bis(pinacol)diborane; With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 3-(2-(2-(dicyclohexylboraneyl)ethyl)phenyl)-1,10-phenanthroline; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In 1,4-dioxane; at 25 ℃; for 0.166667h; Inert atmosphere; Glovebox;

2-(methoxymethyl)pyridine; In hexane; at 25 ℃; for 18h; Overall yield = 80 %; Overall yield = 0.2 g; regioselective reaction; Inert atmosphere; Glovebox;
DOI:10.1021/jacs.9b03138

Reference yield:

: 88139-91-7
(5-bromopyridin-2-yl)methanol

: 1430401-34-5
2-(methoxymethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

1.2: -20 °C / Inert atmosphere

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 4 h / 85 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium hydride; In tetrahydrofuran; 1,4-dioxane; 2.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.6b00519