tert-Butyl 4-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)piperidine-1-carboxyl96%

Base Information

• Chemical Name: tert-Butyl 4-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)piperidine-1-carboxyl96%
• CAS No.: 1246372-53-1
• Molecular Formula: C23H36BNO6
• Molecular Weight: 433.353
• Hs Code.: 2934999090
• Mol file: 1246372-53-1.mol

Synonyms:4-(1-BOC-piperidin-4-yloxy)-3-methoxyphenylboronic acid, pinacol ester;tert-Butyl 4-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)piperidine-1-carboxyl96%

Chemical Property of tert-Butyl 4-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)piperidine-1-carboxyl96%

Chemical Property:

• PSA: 66.46000
• LogP: 3.71060

Purity/Quality:

95% ^*data from raw suppliers

4-(1-Boc-Piperidin-4-yloxy)-3-methoxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 4-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)piperidine-1-carboxyl96%

There total 1 articles about tert-Butyl 4-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)piperidine-1-carboxyl96% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-3-methoxyphenylboronic acid pinacol ester (269410-22-2) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → tert-butyl 4-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)piperidine-1-carboxylate (1246372-53-1)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

2-bromo-5-iodoimidazo[2,1-b][1,3,4]thiadiazole (1246372-52-0) + tert-butyl 4-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)piperidine-1-carboxylate (1246372-53-1) → 4-[4-(5-iodo-imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-2-methoxy-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester (1246372-54-2)

Guidance literature:

With caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; at 115 ℃;

Reference yield:

tert-butyl 4-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)piperidine-1-carboxylate (1246372-53-1) → 4-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)piperidine hydrochloride salt

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 2h;

upstream raw materials:

4-hydroxy-3-methoxyphenylboronic acid pinacol ester

t-butyl 4-hydroxy piperidine-1-carboxylate

Downstream raw materials:

4-[4-(5-iodo-imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-2-methoxy-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester

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