5-(Thiophen-3-yl)pyrazin-2-amine

Base Information

Chemical Name:5-(Thiophen-3-yl)pyrazin-2-amine
CAS No.:710323-21-0
Molecular Formula:C8H7N3S
Molecular Weight:177.23
Hs Code.:2934999090
DSSTox Substance ID:DTXSID10470013
Wikidata:Q82297970
Mol file:710323-21-0.mol

Synonyms:5-(Thiophen-3-yl)pyrazin-2-amine;710323-21-0;5-thiophen-3-ylpyrazin-2-amine;5-thiophen-3-yl-pyrazin-2-ylamine;5-(3-Thienyl)-2-pyrazinamine;5-(3-THIENYL)-2-PYRAZINAMINE,95+%;SCHEMBL2644971;DTXSID10470013;TVLIZLWEJGLKAS-UHFFFAOYSA-N;AKOS006323473;FT-0723782;I11191;A1-14184

Suppliers and Price of 5-(Thiophen-3-yl)pyrazin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
5-Thiophen-3-yl-pyrazin-2-ylamine 95%
5g
$ 1816.00

Crysdot
5-(Thiophen-3-yl)pyrazin-2-amine 95+%
1g
$ 451.00

Chemenu
5-(thiophen-3-yl)pyrazin-2-amine 95%
1g
$ 426.00

Alichem
5-(Thiophen-3-yl)pyrazin-2-amine
1g
$ 455.00

A1 Biochem Labs
5-Thiophen-3-yl-pyrazin-2-ylamine 95%
5 g
$ 1100.00

Total 5 raw suppliers

Chemical Property of 5-(Thiophen-3-yl)pyrazin-2-amine

Chemical Property:

Vapor Pressure:0.001mmHg at 25°C
Boiling Point:309.19°C at 760 mmHg
PKA:3.10±0.10(Predicted)
Flash Point:140.794°C
PSA：80.04000
Density:1.333g/cm³
LogP:2.36850
Storage Temp.:2-8°C
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:177.03606841
Heavy Atom Count:12
Complexity:153

Purity/Quality:

95+% ^*data from raw suppliers

5-Thiophen-3-yl-pyrazin-2-ylamine 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CSC=C1C2=CN=C(C=N2)N

Technology Process of 5-(Thiophen-3-yl)pyrazin-2-amine

There total 1 articles about 5-(Thiophen-3-yl)pyrazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 59489-71-3
5-amino-2-bromopyrazine

: 6165-69-1
Thien-3-ylboronic acid

: 710323-21-0
5-thiophen-3-yl-pyrazin-2-ylamine

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In DMF (N,N-dimethyl-formamide); at 100 ℃; for 16h;

Reference yield: 47.5%

: 710323-21-0
5-thiophen-3-yl-pyrazin-2-ylamine

: 300356-14-3
(R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid

: 710321-99-6
2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-thiophen-3-yl-pyrazin-2-yl)-propionamide

Guidance literature:: With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at 0 ℃; for 0.0833333h;

(R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid; In dichloromethane; at 25 ℃; for 0.25h;

5-thiophen-3-yl-pyrazin-2-ylamine; With pyridine; In dichloromethane; at 25 ℃; for 1.5h;

Reference yield:

: 710323-21-0
5-thiophen-3-yl-pyrazin-2-ylamine

: N-(3-(5-(thiophen-3-yl)pyrazin-2-ylamino)phenyl)-2-(diethylamino)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: Bromoform; isopentyl nitrite / Heating / reflux

2.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 1 h / 120 °C / Microwave irradiation

3.1: hydrogenchloride; methanol; water / 1 h / 65 °C

3.2: pH 8 / Saturated solution

4.1: dichloromethane / 0.17 h / 20 °C

4.2: 0.17 h / Saturated solution

5.1: acetonitrile / 4.5 h / Heating / reflux

With hydrogenchloride; methanol; Bromoform; water; caesium carbonate; isopentyl nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In dichloromethane; toluene; acetonitrile;