4-Chloro-2,5-difluoroiodobenzene

Base Information

• Chemical Name: 4-Chloro-2,5-difluoroiodobenzene
• CAS No.: 1097871-23-2
• Molecular Formula: C6H2ClF2I
• Molecular Weight: 274.436
• Mol file: 1097871-23-2.mol

Synonyms:4-Chloro-2,5-difluoroiodobenzene

Chemical Property of 4-Chloro-2,5-difluoroiodobenzene

Chemical Property:

• PSA: 0.00000
• LogP: 3.22280

Purity/Quality:

99% ^*data from raw suppliers

1-Chloro-2,5-difluoro-4-iodobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-2,5-difluoroiodobenzene

There total 1 articles about 4-Chloro-2,5-difluoroiodobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-chloro-2,5-difluorobenzene (2367-91-1) → 1-chloro-2,5-difluoro-4-iodobenzene (1097871-23-2)

Guidance literature:

With N-iodo-succinimide; trifluorormethanesulfonic acid; at 0 - 20 ℃; for 2.16667h;

Reference yield: 69.0%

1-chloro-2,5-difluoro-4-iodobenzene (1097871-23-2) + C27H27BO3 → C27H17ClF2O

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; toluene; at 100 ℃; for 12h; Inert atmosphere;

Reference yield: 58.0%

1-chloro-2,5-difluoro-4-iodobenzene (1097871-23-2) + diethyl malonate (105-53-3) → diethyl 2-(4-chloro-2,5-difluorophenyl)malonate (1097871-27-6)

Guidance literature:

With copper(l) iodide; caesium carbonate; 2-Phenylphenol; In tetrahydrofuran; at 90 ℃; for 12h;

upstream raw materials:

1-chloro-2,5-difluorobenzene

Downstream raw materials:

diethyl 2-(4-chloro-2,5-difluorophenyl)malonate