2,6-Dichloro-4-iodopyridine-3-carboxylic acid

Base Information

Chemical Name:2,6-Dichloro-4-iodopyridine-3-carboxylic acid
CAS No.:343781-55-5
Molecular Formula:
Molecular Weight:317.9
Hs Code.:
European Community (EC) Number:856-418-6
Nikkaji Number:J1.537.728C
Mol file:343781-55-5.mol

Synonyms:2,6-dichloro-4-iodopyridine-3-carboxylic acid;343781-55-5;2,6-Dichloro-4-iodonicotinic acid;SCHEMBL12563879;2,6-Dichloro-4-iodonicotinicacid;MFCD16658922;AKOS016038718;AS-47164;CS-0134070;FT-0761631;EN300-214847;F12417;Z1269116149

Suppliers and Price of 2,6-Dichloro-4-iodopyridine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2,6-Dichloro-4-iodonicotinicacid 97%
1g
$ 474.00

Chemenu
2,6-dichloro-4-iodopyridine-3-carboxylicacid 95%+
10g
$ 7187.00

Total 5 raw suppliers

Chemical Property of 2,6-Dichloro-4-iodopyridine-3-carboxylic acid

Chemical Property:

Boiling Point:397.6±42.0 °C(Predicted)
PKA:0.43±0.28(Predicted)
Density:2.252±0.06 g/cm3(Predicted)
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:316.85073
Heavy Atom Count:12
Complexity:192

Purity/Quality:

99% ^*data from raw suppliers

2,6-Dichloro-4-iodonicotinicacid 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C(C(=C(N=C1Cl)Cl)C(=O)O)I

Technology Process of 2,6-Dichloro-4-iodopyridine-3-carboxylic acid

There total 3 articles about 2,6-Dichloro-4-iodopyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 124-38-9,18923-20-1
carbon dioxide

: 148493-37-2
2,6-dichloro-3-iodo-pyridine

: 343781-55-5
2,6-dichloro-4-iodo-3-pyridinecarboxylic acid

Guidance literature:: 2,6-dichloro-3-iodo-pyridine; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -75 ℃; for 2h;

carbon dioxide; at -78 ℃;
DOI:10.1002/1099-0690(200104)2001:7<1371::AID-EJOC1371>3.0.CO;2-E

Reference yield: 51.0%

: 98027-84-0
2,6-dichloro-4-iodopyridine

: 124-38-9,18923-20-1
carbon dioxide

: 343781-55-5
2,6-dichloro-4-iodo-3-pyridinecarboxylic acid

Guidance literature:: 2,6-dichloro-4-iodopyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

carbon dioxide; In tetrahydrofuran; at -78 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 2402-78-0
2,6-dichloropyridine

: 343781-55-5
2,6-dichloro-4-iodo-3-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C

1.2: 72 percent / iodine / tetrahydrofuran

2.1: lithium diisopropylamide / tetrahydrofuran; hexane / 2 h / -75 °C

2.2: 57 percent / -78 °C

With n-butyllithium; diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1002/1099-0690(200104)2001:7<1371::AID-EJOC1371>3.0.CO;2-E