1-(2-Methoxyphenyl)-3-methylpiperazine

Base Information

• Chemical Name: 1-(2-Methoxyphenyl)-3-methylpiperazine
• CAS No.: 52807-17-7
• Molecular Formula: C12H18N2O
• Molecular Weight: 226.275
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID90602375
• Nikkaji Number: J741.073E
• Mol file: 52807-17-7.mol

Synonyms:1-(2-Methoxyphenyl)-3-methylpiperazine;152943-96-9;52807-17-7;SCHEMBL25407029;DTXSID90602375;CGA94396;MFCD06804057;AKOS003655993;AKOS016339752;SS-2433;DA-09942;CS-0334016;J-503041

Chemical Property of 1-(2-Methoxyphenyl)-3-methylpiperazine

Chemical Property:

• Melting Point: 108-109 °C
• Boiling Point: 331.0±17.0 °C(Predicted)
• PSA: 24.50000
• Density: 1.076±0.06 g/cm3(Predicted)
• LogP: 1.88710
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 206.141913202
• Heavy Atom Count: 15
• Complexity: 198

Purity/Quality:

98%Min ^*data from raw suppliers

1-(2-methoxyphenyl)-3-methylpiperazinedihydrochloridedihydrate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CN(CCN1)C2=CC=CC=C2OC

Technology Process of 1-(2-Methoxyphenyl)-3-methylpiperazine

There total 29 articles about 1-(2-Methoxyphenyl)-3-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Methoxyphenylboronic acid (5720-06-9) + para-bromoacetophenone (99-90-1) → 4-acetyl-2'-methoxybiphenyl (52807-17-7)

Guidance literature:

With sodium carbonate; palladium on activated charcoal; In ethanol; at 20 ℃; for 4h;

DOI:10.1055/s-2004-837298

Reference yield: 100.0%

4-Iodoacetophenone (13329-40-3) + 2-Methoxyphenylboronic acid (5720-06-9) → 4-acetyl-2'-methoxybiphenyl (52807-17-7)

Guidance literature:

With trihexyl(tetradecyl)phosphonium chloride; potassium phosphate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene; at 50 ℃; for 1h;

DOI:10.1039/b204699g

Reference yield: 99.0%

2-Methoxyphenylboronic acid (5720-06-9) + para-chloroacetophenone (99-91-2) → 4-acetyl-2'-methoxybiphenyl (52807-17-7)

Guidance literature:

With (η³-2-methylallyl)Pd(N3)(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene); caesium carbonate; In methanol; at 80 ℃; for 1h; Schlenk technique;

DOI:10.1002/ejic.201300608

upstream raw materials:

4-acetophenyl triflate

2-tri-n-butylstannylanisole

4-Iodoacetophenone

2-Methoxyphenylboronic acid