Defactinib

Base Information

Chemical Name:Defactinib
CAS No.:1073154-85-4
Molecular Formula:C20H21F3N8O3S
Molecular Weight:510.5
Hs Code.:
Mol file:1073154-85-4.mol

Synonyms:Defactinib;VS 6063;VS6063;VS-6063;Defactinib(PF-04554878);N-methyl-4-(4-((3-(N-methylmethan-3-ylsulfonamido)pyrazin-2-yl)methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzamide;N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide Defactinib(PF-04554878)(VS-6063);N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide

Suppliers and Price of Defactinib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Defactinib
100mg
$ 1380.00

TRC
Defactinib
50mg
$ 170.00

DC Chemicals
Defactinib(VS-6063,PF-04554878) >98%
1 g
$ 1500.00

DC Chemicals
Defactinib(VS-6063,PF-04554878) >98%
250 mg
$ 750.00

Crysdot
Defactinib 98+%
50mg
$ 341.00

Crysdot
Defactinib 98+%
250mg
$ 738.00

Crysdot
Defactinib 98+%
100mg
$ 477.00

ChemScene
Defactinib 99.87%
100mg
$ 420.00

ChemScene
Defactinib 99.87%
50mg
$ 300.00

ChemScene
Defactinib 99.87%
5mg
$ 84.00

Total 21 raw suppliers

Chemical Property of Defactinib

Chemical Property:

PKA:15.16±0.46(Predicted)
PSA：153.71000
Density:1.495±0.06 g/cm3(Predicted)
LogP:3.36310
Storage Temp.:-20°C (des.)
Solubility.:Soluble in DMSO (up to at least 25mg/ml)

Purity/Quality:

99%, ^*data from raw suppliers

Defactinib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays a vital role in many oncogenic pathways. Defactinib is a dose-dependent inhibitor of FAK, with maximal inhibition of FAK autophosphorylation in cells achieved at 10 μM. It is less effective against the related kinase PYK2. Defactinib restores the chemosensitivity of taxane-resistant cells to paclitaxel , although it is not cytotoxic alone. Defactinib decreases YB-1 phosphorylation and nuclear accumulation in an Akt-dependent manner. It is orally bioavailable, inhibiting FAK and augmenting paclitaxel action in suppressing the growth and number of ovarian cancer cell tumors in mice.
Uses Defactinib is a selective and orally active FAK inhibitor phase 2. Used in treating cancer patients as it decreases proliferation and increases apoptosis.

Technology Process of Defactinib

There total 2 articles about Defactinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%