FAK inhibitors
FAK inhibitors, also known as focal adhesion kinase inhibitors, are a class of pharmaceutical compounds designed to target and inhibit the focal adhesion kinase (FAK) protein. FAK is a non-receptor tyrosine kinase that plays a crucial role in integrin-mediated signaling pathways involved in cell adhesion, migration, proliferation, and survival. Overexpression and dysregulation of FAK are implicated in various cancers, including breast, ovarian, and prostate cancers, where it promotes tumor growth, invasion, and metastasis. FAK inhibitors work by binding to the ATP-binding site of the FAK kinase domain, thereby blocking its enzymatic activity and disrupting downstream signaling cascades that promote cancer cell survival and spread. By inhibiting FAK, these inhibitors aim to suppress tumor growth, reduce metastatic potential, and sensitize cancer cells to other therapeutic interventions.
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![N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide](http://file1.lookchem.com/300w/substances/2022-02-14-06/8b7b801e-5622-4bfd-bfa4-03c9391f8eae.png)
![N-Methyl-N-[3-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide](http://file1.lookchem.com/300w/substances/2022-02-18-07/a3b7a196-d829-4ec6-88e2-c7700e32e04d.png)
