2-(4-Bromophenyl)-1-(pyrrolidin-1-yl)ethanone

Base Information

Chemical Name:2-(4-Bromophenyl)-1-(pyrrolidin-1-yl)ethanone
CAS No.:13734-66-2
Molecular Formula:C12H14BrNO
Molecular Weight:268.153
Hs Code.:
DSSTox Substance ID:DTXSID001328562
ChEMBL ID:CHEMBL1867852

Synonyms:2-(4-bromophenyl)-1-(pyrrolidin-1-yl)ethanone;13734-66-2;2-(4-bromophenyl)-1-pyrrolidin-1-ylethanone;Cambridge id 6210455;MLS001185501;SCHEMBL2646798;CHEMBL1867852;DTXSID001328562;HMS2849F11;MFCD01175581;STK082376;AKOS003236894;AM86570;SMR000503147;N10185;AB00104321-01;SR-01000230670;SR-01000230670-1;2-(4-BROMOPHENYL)-1-(PYRROLIDIN-1-YL)ETHAN-1-ONE

Suppliers and Price of 2-(4-Bromophenyl)-1-(pyrrolidin-1-yl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 2-(4-Bromophenyl)-1-(pyrrolidin-1-yl)ethanone

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:267.02588
Heavy Atom Count:15
Complexity:218

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(C1)C(=O)CC2=CC=C(C=C2)Br

Technology Process of 2-(4-Bromophenyl)-1-(pyrrolidin-1-yl)ethanone

There total 5 articles about 2-(4-Bromophenyl)-1-(pyrrolidin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 123-75-1
pyrrolidine

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 13734-66-2
2-(4-bromophenyl)-1-(pyrrolidin-1-yl)ethanone

Guidance literature:: 2-(4-bromophenyl)-acetic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; Inert atmosphere;

pyrrolidine; In dichloromethane; Inert atmosphere;
DOI:10.1039/c7cc04170e

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: C₆H₁₀ClNOZn

: 13734-66-2
2-(4-bromophenyl)-1-(pyrrolidin-1-yl)ethanone

Guidance literature:: With 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; toluene; at 65 ℃; for 5h; chemoselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1016/j.tet.2013.12.053

Reference yield:

: 4030-18-6
N-(acetyl)pyrrolidine

: 13734-66-2
2-(4-bromophenyl)-1-(pyrrolidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hexamethyldisilazane / tetrahydrofuran; toluene / 1 h / 0 - 5 °C / Inert atmosphere; Sealed tube

2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / tetrahydrofuran; toluene / 5 h / 65 °C / Inert atmosphere; Sealed tube

With sodium hexamethyldisilazane; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; toluene; 2: |Reformatsky Reaction;
DOI:10.1016/j.tet.2013.12.053