(R)-5-METHOXY-2,3-DIHYDRO-1H-INDEN-1-AMINE

Base Information

• Chemical Name: (R)-5-METHOXY-2,3-DIHYDRO-1H-INDEN-1-AMINE
• CAS No.: 132154-13-3
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.219
• Mol file: 132154-13-3.mol

Synonyms:(R)-5-METHOXY-2,3-DIHYDRO-1H-INDEN-1-AMINE;(1R)-2,3-DIHYDRO-5-METHOXY-1H-INDEN-1-AMINE;(1R)-5-METHOXYINDANYLAMINE

Chemical Property of (R)-5-METHOXY-2,3-DIHYDRO-1H-INDEN-1-AMINE

Chemical Property:

• PSA: 35.25000
• LogP: 2.34150

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-5-METHOXY-2,3-DIHYDRO-1H-INDEN-1-AMINE

There total 10 articles about (R)-5-METHOXY-2,3-DIHYDRO-1H-INDEN-1-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-azido-5-methoxy-2,3-dihydro-1H-indene → 2,3-dihydro-5-methoxy-1H-inden-1-amine (52372-95-9,132154-13-3,132154-15-5)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; for 3h;

Reference yield: 61.0%

5-methoxy-1-indanone oxime (90921-94-1) → 2,3-dihydro-5-methoxy-1H-inden-1-amine (52372-95-9,132154-13-3,132154-15-5)

Guidance literature:

5-methoxy-1-indanone oxime; With lithium aluminium tetrahydride; In diethyl ether; at -78 - 40 ℃; for 5h;

With sodium hydroxide; water; In diethyl ether; at 0 ℃;

Reference yield: 52.0%

5-methoxy-1-indanone (5111-70-6) → 2,3-dihydro-5-methoxy-1H-inden-1-amine (52372-95-9,132154-13-3,132154-15-5)

Guidance literature:

5-methoxy-1-indanone; With titanium(IV) isopropylate; ammonia; In isopropyl alcohol; at 20 ℃;

With sodium tetrahydroborate; In isopropyl alcohol; at 20 ℃; for 2h;

DOI:10.1002/chir.22856

upstream raw materials:

5-methoxy-1-indanone oxime

acetic acid

5-methoxy-1-indanone

2,3-dihydro-5-methoxy-1H-inden-1-one O-methyloxime

Refernces

• 1、 Issaraseriruk, Natthapol,Sritana-anant, Yongsak,Shitangkoon, Aroonsiri. "Substituent effects on chiral resolutions of derivatized 1-phenylalkylamines by heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin GC stationary phase". supporting information. p. 900 - 906. Retrieved 2018/05/08.
• 2、 -. "Comestible compositions comprising high potency savory flavorants, and processes for producing them". Page/Page column 64. . Retrieved 2012/04/10.