Dronedarone-d6 Hydrochloride

Base Information

Chemical Name:Dronedarone-d6 Hydrochloride
CAS No.:1329809-23-5
Molecular Formula:C31H45ClN2O5S
Molecular Weight:593.2174
Hs Code.:
Mol file:1329809-23-5.mol

Synonyms:Dronedarone-d6 Hydrochloride;Multaq-d6 Hydrochloride;N-[2-Butyl-3-[4-[3-(dibutylaMino)propoxy]benzoyl]-5-benzofuranyl]MethanesulfonaMide-d6 Hydrochloride;SR33589-d6 Hydrochloride

Suppliers and Price of Dronedarone-d6 Hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Dronedarone-d6 Hydrochloride
1mg
$ 496.00

TRC
Dronedarone-d6Hydrochloride
1mg
$ 215.00

Total 6 raw suppliers

Chemical Property of Dronedarone-d6 Hydrochloride

Chemical Property:

Melting Point:38-40°C
PSA：97.23000
LogP:9.00480
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

>95% ^*data from raw suppliers

Dronedarone-d6 Hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Dronedarone-d6 Hydrochloride is a drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.

Technology Process of Dronedarone-d6 Hydrochloride

There total 4 articles about Dronedarone-d6 Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1542232-47-2
(5-amino-2-butyl-benzofuran-3-yl)-[4-(3-dibutylamino-[²H₆]-propoxy)-phenyl]-methanone

: 124-63-0
methanesulfonyl chloride

: 1329809-23-5
N-{2-butyl-3-[4-(3-dibutylamino-[²H₆]-propoxy)-benzoyl]-benzofuran-5-yl}-methanesulfonamide hydrochloride

Guidance literature:: (5-amino-2-butyl-benzofuran-3-yl)-[4-(3-dibutylamino-[²H₆]-propoxy)-phenyl]-methanone; methanesulfonyl chloride; With ammonia; In tetrahydrofuran; tert-butyl methyl ether; water; at 20 ℃;

With hydrogenchloride; In diethyl ether;
DOI:10.1002/jlcr.3090

Reference yield:

: 1542232-38-1
(2-butyl-5-nitro-benzofuran-3-yl)-[4-(3-dibutylamino-[²H₆]-propoxy)-phenyl]-methanone

: 1329809-23-5
N-{2-butyl-3-[4-(3-dibutylamino-[²H₆]-propoxy)-benzoyl]-benzofuran-5-yl}-methanesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: tin(II) chloride dihdyrate / ethanol / 80 °C / Inert atmosphere

2: ammonia / tetrahydrofuran; water; tert-butyl methyl ether / 20 °C

With tin(II) chloride dihdyrate; ammonia; In tetrahydrofuran; ethanol; tert-butyl methyl ether; water;
DOI:10.1002/jlcr.3090

Reference yield:

: 141645-16-1
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

: 1329809-23-5
N-{2-butyl-3-[4-(3-dibutylamino-[²H₆]-propoxy)-benzoyl]-benzofuran-5-yl}-methanesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / water / 8 h / Reflux

2: dimethyl sulfoxide / 18 h / 20 °C

3: tin(II) chloride dihdyrate / ethanol / 80 °C / Inert atmosphere

4: ammonia / tetrahydrofuran; water; tert-butyl methyl ether / 20 °C

With tin(II) chloride dihdyrate; ammonia; sodium hydroxide; In tetrahydrofuran; ethanol; tert-butyl methyl ether; water; dimethyl sulfoxide;
DOI:10.1002/jlcr.3090