cis-4-Aminotetrahydropyran-3-OL

Base Information

• Chemical Name: cis-4-Aminotetrahydropyran-3-OL
• CAS No.: 1363380-59-9
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.14634
• DSSTox Substance ID: DTXSID001228782
• Mol file: 1363380-59-9.mol

Synonyms:CIS-4-AMINOTETRAHYDROPYRAN-3-OL;1363380-59-9;(3R,4R)-4-Aminotetrahydro-2H-pyran-3-ol;(3R,4R)-4-AMINOOXAN-3-OL;(3R,4R)-rel-4-Aminotetrahydro-2H-pyran-3-ol;1388809-16-2;cis-4-Amino-tetrahydro-pyran-3-ol;(3R,4R)-4-Amino-tetrahydro-pyran-3-ol;SCHEMBL8672791;DTXSID001228782;MFCD22417049;AS-51649;CS-0145122;P13194;erythro-Pentitol, 3-amino-1,5-anhydro-2,3-dideoxy-

Chemical Property of cis-4-Aminotetrahydropyran-3-OL

Chemical Property:

• PSA: 55.48000
• LogP: -0.20480
• XLogP3: -1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 117.078978594
• Heavy Atom Count: 8
• Complexity: 76.8

Purity/Quality:

NLT 98% ^*data from raw suppliers

cis-4-Aminotetrahydropyran-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCC(C1N)O
• Isomeric SMILES: C1COC[C@@H]([C@@H]1N)O

Technology Process of cis-4-Aminotetrahydropyran-3-OL

There total 29 articles about cis-4-Aminotetrahydropyran-3-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3R,S),(4R,S)-4-azidotetrahydropyran-3-ol → (3R,S),(4R,S)-4-aminotetrahydropyran-3-ol (1363380-59-9,1309081-53-5,1390652-01-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 18h; under 2327.23 Torr;

Reference yield: 92.0%

(2R)-2-acetamido-3-phenyl-propanoic acid; (3R,4S)-4-aminotetrahydropyran-3-ol → (3R,4S)-4-aminotetrahydro-2H-pyran-3-ol (1096770-58-9,1363380-59-9,1309081-53-5,1390652-01-3)

Guidance literature:

With AmberlystA₂₆(OH) resin; In methanol; dichloromethane; at 20 ℃;

Reference yield: 38.0%

3,4-epoxytetrahydropyran (286-22-6) → (3S,4S)-3-aminotetrahydro-2H-pyran-4-ol (1309081-45-5,1350734-61-0,1638744-36-1,1638771-36-4) + (3R,S),(4R,S)-4-aminotetrahydropyran-3-ol (1363380-59-9,1309081-53-5,1390652-01-3)

Guidance literature:

With ammonium hydroxide; In methanol; water; at 20 ℃;

DOI:10.1021/acs.jmedchem.7b01812

upstream raw materials:

3,4-epoxytetrahydropyran

dihydropyran

4-bromotetrahydro-2H-pyran

4-oxanyl methanesulfonate

Refernces

• 1、 -. "BENZOISOQUINOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS". . . Retrieved 2018/02/28.
• 2、 -. "QUINAZOLINE COMPOUNDS USEFUL AS M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS". . . Retrieved 2017/09/27.