Methyl 3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropanoate

Base Information

• Chemical Name: Methyl 3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropanoate
• CAS No.: 153744-36-6
• Molecular Formula: C12H11NO5
• Molecular Weight: 249.223
• Mol file: 153744-36-6.mol

Synonyms:Methyl 3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropanoate

Chemical Property of Methyl 3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropanoate

Chemical Property:

• Boiling Point: 432.0±35.0 °C(Predicted)
• PKA: 12.23±0.20(Predicted)
• PSA: 83.91000
• Density: 1.427±0.06 g/cm3(Predicted)
• LogP: -0.24560
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropanoate

There total 3 articles about Methyl 3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 2-hydroxy-3-phthalimidopropanoic acid (62983-58-8) → methyl 3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropanoate (153744-36-6)

Guidance literature:

With hydrogenchloride;

Reference yield:

phthalic anhydride (85-44-9) → methyl 3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropanoate (153744-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 160 °C

2: hydrochloric acid

With hydrogenchloride;

Reference yield:

phthalic anhydride (85-44-9) → methyl 3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropanoate (153744-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.5 h / 145 °C

2: SOCl₂ / 17 h / Ambient temperature

With thionyl chloride;

DOI:10.1016/S0957-4166(00)80068-3

upstream raw materials:

methanol

2-hydroxy-3-phthalimidopropanoic acid

phthalic anhydride

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