2-(4-broMophenyl)-2-Methylpropanoyl chloride

Base Information

• Chemical Name: 2-(4-broMophenyl)-2-Methylpropanoyl chloride
• CAS No.: 1040860-77-2
• Molecular Formula: C10H10BrClO
• Molecular Weight: 261.5428
• Mol file: 1040860-77-2.mol

Synonyms:2-(4-broMophenyl)-2-Methylpropanoyl chloride;2-(4-bromophenyl)-2-methylpropanoic acid chloride

Chemical Property of 2-(4-broMophenyl)-2-Methylpropanoyl chloride

Chemical Property:

• PSA: 17.07000
• LogP: 3.49210

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-broMophenyl)-2-Methylpropanoyl chloride

There total 2 articles about 2-(4-broMophenyl)-2-Methylpropanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-bromophenyl)-2-methylpropionic acid (32454-35-6) → 2-(4-bromophenyl)-2-methylpropanoic acid chloride (1040860-77-2)

Guidance literature:

With thionyl chloride; for 2h; Heating / reflux;

Reference yield:

methyl 2-(4-bromophenyl)-2,2-dimethylacetate (154825-97-5) → 2-(4-bromophenyl)-2-methylpropanoic acid chloride (1040860-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide; ethanol; water / 15 h / 90 °C

1.2: pH 2.0

2.1: thionyl chloride / 2 h / Heating / reflux

With potassium hydroxide; thionyl chloride; ethanol; water;

Reference yield:

2-(4-bromophenyl)-2-methylpropanoic acid chloride (1040860-77-2) + diethyl malonate (105-53-3) → diethyl 2-(2-(4-bromophenyl)-2-methylpropanoyl)malonate (1035261-71-2)

Guidance literature:

diethyl malonate; With tetrachloromethane; magnesium; In tetrahydrofuran; ethanol; at 23 ℃; for 1.5h; Heating / reflux;

2-(4-bromophenyl)-2-methylpropanoic acid chloride; In tetrahydrofuran; ethanol; for 0.5h; Heating / reflux;

upstream raw materials:

2-(4-bromophenyl)-2-methylpropionic acid

methyl 2-(4-bromophenyl)-2,2-dimethylacetate

Downstream raw materials:

diethyl 2-(2-(4-bromophenyl)-2-methylpropanoyl)malonate

Refernces