(4-Methyloxan-4-yl)methanamine

Base Information

• Chemical Name: (4-Methyloxan-4-yl)methanamine
• CAS No.: 65626-24-6
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.202
• Hs Code.: 2932999099
• European Community (EC) Number: 839-891-3
• DSSTox Substance ID: DTXSID70709472
• Wikidata: Q82644431
• Mol file: 65626-24-6.mol

Synonyms:(4-methyloxan-4-yl)methanamine;65626-24-6;4-AMINOMETHYL-4-METHYLTETRAHYDRO-2H-PYRAN;(4-METHYLTETRAHYDRO-2H-PYRAN-4-YL)METHANAMINE;1-(4-METHYLTETRAHYDRO-2H-PYRAN-4-YL)METHANAMINE;SCHEMBL92847;DTXSID70709472;ORECGNYKJRNVMQ-UHFFFAOYSA-N;1-(4-Methyloxan-4-yl)methanamine;AMY34437;MFCD13184219;AKOS012204028;PB34762;BS-13125;C-(4-Methyltetrahydropyran-4-yl)methylamine;CS-0053196;EN300-123415

Chemical Property of (4-Methyloxan-4-yl)methanamine

Chemical Property:

• PSA: 35.25000
• LogP: 1.46210
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 129.115364102
• Heavy Atom Count: 9
• Complexity: 86.9

Purity/Quality:

98%,99%, ^*data from raw suppliers

(4-Methyltetrahydro-2H-pyran-4-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CCOCC1)CN

Technology Process of (4-Methyloxan-4-yl)methanamine

There total 2 articles about (4-Methyloxan-4-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyltetrahydro-2H-pyran-4-carbonitrile (856255-87-3) → (4-methyltetrahydro-2H-pyran-4-yl)methanamine (65626-24-6)

Guidance literature:

4-methyltetrahydro-2H-pyran-4-carbonitrile; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 3.25h;

With water; sodium hydroxide; In tetrahydrofuran;

Reference yield:

tetrahydro-2H-pyran-4-carbonitrile (4295-99-2) → (4-methyltetrahydro-2H-pyran-4-yl)methanamine (65626-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 5 °C

1.2: 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.25 h / 0 - 20 °C

With lithium aluminium tetrahydride; lithium hexamethyldisilazane; In tetrahydrofuran;

Reference yield:

(4-methyltetrahydro-2H-pyran-4-yl)methanamine (65626-24-6) → N2'-(trans-4-aminocyclohexyl)-5'-chloro-N6-((4-methyltetrahydro-2H-pyran-4-yl)methyl)-2,4'-bipyridine-2',6-diamine trifluoroacetate

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dimethyl sulfoxide / 18 h / 110 °C

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 4 h / 103 °C

3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 107 °C

With sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dimethyl sulfoxide;

upstream raw materials:

4-methyltetrahydro-2H-pyran-4-carbonitrile

tetrahydro-2H-pyran-4-carbonitrile

Downstream raw materials:

6-bromo-N-((4-methyltetrahydro-2H-pyran-4-yl)methyl)pyridin-2-amine

6-(benzyloxy)-3-fluoro-N-((4-methyltetrahydro-2H-pyran-4-yl)methyl)pyridin-2-amine

Refernces

• 1、 -. "NOVEL SUBSTITUTED INDANES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS DRUGS". Page/Page column 64. . Retrieved 2012/02/03.
• 2、 -. "3-(AMINOARYL)-PYRIDINE COMPOUNDS". Page/Page column 88. . Retrieved 2012/06/01.