7-Chloro-4'-hydroxy-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-cyclohexan]-3-one

Base Information

Chemical Name:7-Chloro-4'-hydroxy-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-cyclohexan]-3-one
CAS No.:26891-87-2
Molecular Formula:C₁₇H₂₁ClO₆
Molecular Weight:356.803
Hs Code.:
Mol file:26891-87-2.mol

Synonyms:7-Chloro-4'-hydroxy-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-cyclohexan]-3-one

Suppliers and Price of 7-Chloro-4'-hydroxy-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-cyclohexan]-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-Chloro-4'-hydroxy-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-cyclohexan]-3-one

Chemical Property:

Melting Point:197 - 198 °C (benzene)
Boiling Point:527.9±50.0 °C(Predicted)
PKA:14.31±0.60(Predicted)
PSA：74.22000
Density:1.35±0.1 g/cm3(Predicted)
LogP:2.47690

Purity/Quality:

Safty Information:

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Technology Process of 7-Chloro-4'-hydroxy-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-cyclohexan]-3-one

There total 2 articles about 7-Chloro-4'-hydroxy-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-cyclohexan]-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126-07-8
griseofulvin

: 26891-87-2
(2S,2'Ξ,4'Ξ,6'R)-7-chloro-4'-hydroxy-4,6,2'-trimethoxy-6'-methyl-spiro[benzofuran-2,1'-cyclohexan]-3-one

Guidance literature:: With acetic acid; platinum; Hydrogenation;
DOI:10.1039/jr9520003994

Reference yield:

: 64-19-7,77671-22-8
acetic acid

: 126-07-8
griseofulvin

: (2S,2'Ξ,6'R)-7-chloro-4,6,2'-trimethoxy-6'-methyl-spiro[benzofuran-2,1'-cyclohexan]-3-one

: 26891-87-2
(2S,2'Ξ,4'Ξ,6'R)-7-chloro-4'-hydroxy-4,6,2'-trimethoxy-6'-methyl-spiro[benzofuran-2,1'-cyclohexan]-3-one

Guidance literature:: Irradiation;
DOI:10.1039/jr9520003994

Reference yield:

: 26891-87-2
(2S,2'Ξ,4'Ξ,6'R)-7-chloro-4'-hydroxy-4,6,2'-trimethoxy-6'-methyl-spiro[benzofuran-2,1'-cyclohexan]-3-one

: 17793-65-6,17794-02-4,86594-42-5
(+)-2'-demethoxy-2',3'-dihydrogriseofulvin

Guidance literature:: Multi-step reaction with 3 steps

1: chromium (VI)-oxide; aqueous acetic acid

2: aq.-ethanolic sulfuric acid

3: Raney nickel; chloroform; ethanol / Hydrogenation

With chromium(VI) oxide; ethanol; chloroform; sulfuric acid; nickel; acetic acid;
DOI:10.1039/jr9520003994