(2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-((4-NITROBENZYLOXY)METHOXY)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE

Base Information

Chemical Name:(2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-((4-NITROBENZYLOXY)METHOXY)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE
CAS No.:175473-95-7
Molecular Formula:C₄₇H₅₄N₅O₁₂P
Molecular Weight:911.946
Hs Code.:
Mol file:175473-95-7.mol

(2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-((4-NITROBENZYLOXY)METHOXY)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE

Synonyms:(2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-((4-NITROBENZYLOXY)METHOXY)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE

Suppliers and Price of (2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-((4-NITROBENZYLOXY)METHOXY)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-((4-NITROBENZYLOXY)METHOXY)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-((4-NITROBENZYLOXY)METHOXY)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE

There total 7 articles about (2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-((4-NITROBENZYLOXY)METHOXY)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58-96-8
uridine

: 175473-95-7
C₄₇H₅₄N₅O₁₂P

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 3 h / 25 °C

2: acetic acid; Ac₂O / 48 h / 25 °C

3: N-iodosuccinimide; trifluoromethanesulfonic acid / 1,2-dichloro-ethane; diethyl ether / 0 °C

4: ammonium fluoride / methanol / 16 h / 25 °C

5: pyridine / 2 h / 25 °C

6: triethylamine / CH₂Cl₂ / 2 h / 25 °C

With pyridine; N-iodo-succinimide; ammonium fluoride; trifluorormethanesulfonic acid; acetic anhydride; acetic acid; triethylamine; In methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol0629824

Reference yield:

: 174497-93-9
2'-O-methylthiomethyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 175473-95-7
C₄₇H₅₄N₅O₁₂P

Guidance literature:: Multi-step reaction with 4 steps

1: N-iodosuccinimide; trifluoromethanesulfonic acid / 1,2-dichloro-ethane; diethyl ether / 0 °C

2: ammonium fluoride / methanol / 16 h / 25 °C

3: pyridine / 2 h / 25 °C

4: triethylamine / CH₂Cl₂ / 2 h / 25 °C

With pyridine; N-iodo-succinimide; ammonium fluoride; trifluorormethanesulfonic acid; triethylamine; In methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol0629824

Reference yield:

: 69304-38-7
3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 175473-95-7
C₄₇H₅₄N₅O₁₂P

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; Ac₂O / 48 h / 25 °C

2: N-iodosuccinimide; trifluoromethanesulfonic acid / 1,2-dichloro-ethane; diethyl ether / 0 °C

3: ammonium fluoride / methanol / 16 h / 25 °C

4: pyridine / 2 h / 25 °C

5: triethylamine / CH₂Cl₂ / 2 h / 25 °C

With pyridine; N-iodo-succinimide; ammonium fluoride; trifluorormethanesulfonic acid; acetic anhydride; acetic acid; triethylamine; In methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol0629824