Technology Process of 3-bromo-2-(bromomethyl)-6-chloro-4-methylpyridine
There total 4 articles about 3-bromo-2-(bromomethyl)-6-chloro-4-methylpyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: urea hydrogen peroxide adduct; trifluoroacetic anhydride / dichloromethane / 2.5 h / 0 - 20 °C
2.1: trifluoroacetic anhydride / dichloromethane / 3 h / 20 °C
2.2: 1.17 h / 0 - 20 °C
3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 16 h / 0 - 20 °C
With
carbon tetrabromide; urea hydrogen peroxide adduct; triphenylphosphine; trifluoroacetic anhydride;
In
dichloromethane;
- Guidance literature:
-
With
carbon tetrabromide; triphenylphosphine;
In
dichloromethane;
at 0 - 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride; sodium nitrite / water / 1.25 h / -10 - 20 °C
1.2: pH 13
2.1: urea hydrogen peroxide adduct; trifluoroacetic anhydride / dichloromethane / 2.5 h / 0 - 20 °C
3.1: trifluoroacetic anhydride / dichloromethane / 3 h / 20 °C
3.2: 1.17 h / 0 - 20 °C
4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 16 h / 0 - 20 °C
With
hydrogenchloride; carbon tetrabromide; urea hydrogen peroxide adduct; triphenylphosphine; trifluoroacetic anhydride; sodium nitrite;
In
dichloromethane; water;
