(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[(3-bromo-6-chloro-4-methylpyridin-2-yl)methyl]-4-methyl-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[(3-bromo-6-chloro-4-methylpyridin-2-yl)methyl]-4-methyl-1,3-oxazolidin-2-one
CAS No.:1374134-47-0
Molecular Formula:C₁₉H₁₄BrClF₆N₂O₂
Molecular Weight:531.68
Hs Code.:

Synonyms:(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[(3-bromo-6-chloro-4-methylpyridin-2-yl)methyl]-4-methyl-1,3-oxazolidin-2-one

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Chemical Property of (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[(3-bromo-6-chloro-4-methylpyridin-2-yl)methyl]-4-methyl-1,3-oxazolidin-2-one

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Technology Process of (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[(3-bromo-6-chloro-4-methylpyridin-2-yl)methyl]-4-methyl-1,3-oxazolidin-2-one

There total 5 articles about (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[(3-bromo-6-chloro-4-methylpyridin-2-yl)methyl]-4-methyl-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 918145-29-6
5-bromo-2-chloro-4,6-dimethylpyridine

: 1374134-47-0
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[(3-bromo-6-chloro-4-methylpyridin-2-yl)methyl]-4-methyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: urea hydrogen peroxide adduct; trifluoroacetic anhydride / dichloromethane / 2.5 h / 0 - 20 °C

2.1: trifluoroacetic anhydride / dichloromethane / 3 h / 20 °C

2.2: 1.17 h / 0 - 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 16 h / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

4.2: 16 h / 20 °C

With carbon tetrabromide; urea hydrogen peroxide adduct; sodium hydride; triphenylphosphine; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; mineral oil;

Reference yield:

: 875444-08-9
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

: 1374128-33-2
3-bromo-2-(bromomethyl)-6-chloro-4-methylpyridine

: 1374134-47-0
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[(3-bromo-6-chloro-4-methylpyridin-2-yl)methyl]-4-methyl-1,3-oxazolidin-2-one

Guidance literature:: (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.166667h;

3-bromo-2-(bromomethyl)-6-chloro-4-methylpyridine; In tetrahydrofuran; mineral oil; at 20 ℃; for 16h;

Reference yield:

: 89856-44-0
2-amino-5-bromo-4,6-dimethylpyridine

: 1374134-47-0
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[(3-bromo-6-chloro-4-methylpyridin-2-yl)methyl]-4-methyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; sodium nitrite / water / 1.25 h / -10 - 20 °C

1.2: pH 13

2.1: urea hydrogen peroxide adduct; trifluoroacetic anhydride / dichloromethane / 2.5 h / 0 - 20 °C

3.1: trifluoroacetic anhydride / dichloromethane / 3 h / 20 °C

3.2: 1.17 h / 0 - 20 °C

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 16 h / 0 - 20 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

5.2: 16 h / 20 °C

With hydrogenchloride; carbon tetrabromide; urea hydrogen peroxide adduct; sodium hydride; triphenylphosphine; trifluoroacetic anhydride; sodium nitrite; In tetrahydrofuran; dichloromethane; water; mineral oil;