S-1-Methyl-3-(Boc-aMino)pyrrolidine

Base Information

• Chemical Name: S-1-Methyl-3-(Boc-aMino)pyrrolidine
• CAS No.: 852874-60-3
• Molecular Formula: C10H20N2O2
• Molecular Weight: 200.281
• Hs Code.: 2933990090
• Mol file: 852874-60-3.mol

Synonyms:S-1-Methyl-3-(Boc-aMino)pyrrolidine;N-[(3S)-1-Methyl-3-pyrrolidinyl]carbamic Acid tert-But yl Ester

Chemical Property of S-1-Methyl-3-(Boc-aMino)pyrrolidine

Chemical Property:

• PSA: 23.47000
• LogP: 0.42270

Purity/Quality:

98.5% ^*data from raw suppliers

(S)-tert-Butyl(1-methylpyrrolidin-3-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S-1-Methyl-3-(Boc-aMino)pyrrolidine

There total 5 articles about S-1-Methyl-3-(Boc-aMino)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tert-butyl (3S)-3-(tert-butyloxycarbonylamino)pyrrolidine-1-carboxylate → (S)-tert-butyl 1-methylpyrrolidin-3-ylcarbamate (852874-60-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 24h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetasy.2010.04.038

Reference yield: 77.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3(S)-(tert-butoxycarbonylamino)pyrrolidine (122536-76-9,140629-77-2) → (S)-tert-butyl 1-methylpyrrolidin-3-ylcarbamate (852874-60-3)

Guidance literature:

formaldehyd; 3(S)-(tert-butoxycarbonylamino)pyrrolidine; In methanol; water; 1,2-dichloro-ethane; at 20 ℃; for 0.333333h;

With sodium tris(acetoxy)borohydride; In methanol; water; 1,2-dichloro-ethane; at 20 ℃; for 18h;

DOI:10.1039/c8ob02599a

Reference yield:

(S)-2-(tert-butoxycarbonylamino)-1,4-butanediol (128427-10-1,156627-42-8) → (S)-tert-butyl 1-methylpyrrolidin-3-ylcarbamate (852874-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / Inert atmosphere

2: 16 h / 20 °C / Inert atmosphere

With triethylamine; In dichloromethane;

DOI:10.1021/ol302005f

upstream raw materials:

formaldehyd

3(S)-(tert-butoxycarbonylamino)pyrrolidine

(S)-2-(tert-butoxycarbonylamino)-1,4-butanediol

methylamine

Downstream raw materials:

(S)-N-benzyl-N-methyl-N-(1-methylpyrrolidin-3-yl)amine

(S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-(1-methylpyrrolidine-3-yl)thiourea

(S)-1-(1-methylpiperidine-3-yl)-3-phenylselenourea

2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-N-((S)-1-methylpyrrolidin-3-yl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxamide