GSK591

Base Information

Chemical Name:GSK591
CAS No.:1616391-87-7
Molecular Formula:C22H28N4O2
Molecular Weight:380.48
Hs Code.:
Mol file:1616391-87-7.mol

Synonyms:GSK591;GSK591 (EPZ-015866);EPZ015866;GSK591(EPZ015866,GSK3203591);EPZ015866(GSK591)

Suppliers and Price of GSK591

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
EPZ015866 >98%
250 mg
$ 900.00

DC Chemicals
EPZ015866 >98%
1 g
$ 1800.00

ChemScene
GSK591 99.98%
25mg
$ 444.00

ChemScene
GSK591 99.98%
10mg
$ 216.00

ChemScene
GSK591 99.98%
5mg
$ 132.00

ChemScene
GSK591 99.98%
100mg
$ 1140.00

ChemScene
GSK591 99.98%
50mg
$ 744.00

Cayman Chemical
GSK591 ≥95%
25mg
$ 313.00

Cayman Chemical
GSK591 ≥95%
5mg
$ 75.00

Cayman Chemical
GSK591 ≥95%
1mg
$ 25.00

Total 20 raw suppliers

Chemical Property of GSK591

Chemical Property:

Boiling Point:648.4±55.0 °C(Predicted)
PKA:13.54±0.46(Predicted)
PSA：77.49000
Density:1.252±0.06 g/cm3(Predicted)
LogP:2.59680
Storage Temp.:2-8°C
Solubility.:≥38 mg/mL in DMSO; insoluble in H2O; ≥15.4 mg/mL in EtOH

Purity/Quality:

99%, ^*data from raw suppliers

EPZ015866 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description GSK591 is a chemical probe of PRMT5 (protein arginine methyltransferase 5), which plays a key role in various biological processes. PRMT5 is related to many human diseases including certain cancers like mantle cell lymphoma (MCL). Therefore, GSK591 is a useful tool for testing biological and therapeutic hypotheses. Study has shown that it can potential inhibit the PRMT5/MEP50 complex and symmetric arginine methylation of SMD3.

Technology Process of GSK591

There total 4 articles about GSK591 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 2516-34-9
cyclobutylamine

: (S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-fluoroisonicotinamide

: 1616391-87-7
GSK591

Guidance literature:: With N-ethyl-N,N-diisopropylamine; at 140 ℃; for 1h; Microwave irradiation;
DOI:10.1021/acsmedchemlett.5b00380

Reference yield:

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 1616391-87-7
GSK591

Guidance literature:: Multi-step reaction with 4 steps

1: potassium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

2: ammonia / ethanol / 3 h / 80 °C / Sealed tube

3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 1 h / 5 °C

4: N-ethyl-N,N-diisopropylamine / 1 h / 140 °C / Microwave irradiation

With potassium fluoride; ammonia; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/acsmedchemlett.5b00380

Reference yield:

: 1616077-51-0
(S)-1-amino-3-(3,4-dihydroisoquinolin-2(1H)-yl)-propan-2-ol

: 1616391-87-7
GSK591

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 1 h / 5 °C

2: N-ethyl-N,N-diisopropylamine / 1 h / 140 °C / Microwave irradiation

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane;
DOI:10.1021/acsmedchemlett.5b00380