2-ethoxyethyl 2-(4-chlorophenylamino)pyrimidine-4-carboxylate

Base Information

• Chemical Name: 2-ethoxyethyl 2-(4-chlorophenylamino)pyrimidine-4-carboxylate
• CAS No.: 1428558-35-3
• Molecular Formula: C₁₅H₁₆ClN₃O₃
• Molecular Weight: 321.763
• Mol file: 1428558-35-3.mol

Synonyms:2-ethoxyethyl 2-(4-chlorophenylamino)pyrimidine-4-carboxylate

Chemical Property of 2-ethoxyethyl 2-(4-chlorophenylamino)pyrimidine-4-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of 2-ethoxyethyl 2-(4-chlorophenylamino)pyrimidine-4-carboxylate

There total 1 articles about 2-ethoxyethyl 2-(4-chlorophenylamino)pyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-ethoxy-ethanol (110-80-5) + methyl 2,6-dichloropyrimidine-4-carboxylate (149849-94-5) + 4-chloro-aniline (106-47-8) → 2-ethoxyethyl 2-(4-chlorophenylamino)pyrimidine-4-carboxylate (1428558-35-3)

Guidance literature:

With hydrogenchloride; In water; at 100 ℃; for 18h;

Reference yield: 76.0%

2-ethoxyethyl 2-(4-chlorophenylamino)pyrimidine-4-carboxylate (1428558-35-3) → (2-(4-chlorophenylamino)pyrimidin-4-yl)methanol (1428558-36-4)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -78 - 20 ℃; for 1.5h;

Reference yield:

2-ethoxyethyl 2-(4-chlorophenylamino)pyrimidine-4-carboxylate (1428558-35-3) → C20H15ClN4O2 (1428557-50-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / -78 - 20 °C

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

2.2: 18 h / 20 °C

With diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene;

upstream raw materials:

2-ethoxy-ethanol

methyl 2,6-dichloropyrimidine-4-carboxylate

4-chloro-aniline

Downstream raw materials:

(2-(4-chlorophenylamino)pyrimidin-4-yl)methanol

C₂₀H₁₅ClN₄O₂