methyl 2-chloropyrimidine-4-carboxylate

Base Information

• Chemical Name: methyl 2-chloropyrimidine-4-carboxylate
• CAS No.: 149849-94-5
• Molecular Formula: C6H5 Cl N2 O2
• Molecular Weight: 172.571
• Hs Code.: 2933599090
• Mol file: 149849-94-5.mol

Synonyms:2-Chloropyrimidine-4-carboxylicacid methyl ester; Methyl 2-chloropyrimidine-4-carboxylate

Chemical Property of methyl 2-chloropyrimidine-4-carboxylate

Chemical Property:

• Refractive Index: 1.534
• Boiling Point: 304.3±15.0 °C(Predicted)
• PKA: -3.78±0.20(Predicted)
• PSA: 52.08000
• Density: 1.372±0.06 g/cm3(Predicted)
• LogP: 0.91660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl2-chloropyrimidine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 2-chloropyrimidine-4-carboxylate is an organic ester, which can be used as an intermediate in pharmaceutical synthesis for experimental research and pharmaceutical synthesis.

Technology Process of methyl 2-chloropyrimidine-4-carboxylate

There total 3 articles about methyl 2-chloropyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloropyrimidine-4-carboxylic acid chloride (149849-93-4) → methyl 2,6-dichloropyrimidine-4-carboxylate (149849-94-5)

Guidance literature:

In methanol;

Reference yield: 11.0%

2,6-dichloropyrimidine-4-carboxylic acid methyl ester (6299-85-0) → methyl 2,6-dichloropyrimidine-4-carboxylate (149849-94-5)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In ethanol; at 20 ℃; for 18h; under 1875.19 Torr;

Reference yield:

methanol (67-56-1) + 2‐chloropyrimidine‐4‐carboxylic acid (149849-92-3) → methyl 2,6-dichloropyrimidine-4-carboxylate (149849-94-5)

Guidance literature:

2‐chloropyrimidine‐4‐carboxylic acid; With N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 3h;

methanol; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

upstream raw materials:

2,6-dichloropyrimidine-4-carboxylic acid methyl ester

2-chloropyrimidine-4-carboxylic acid chloride

methanol

2‐chloropyrimidine‐4‐carboxylic acid

Downstream raw materials:

4-(bromomethyl)-2-chloropyrimidine

Refernces

• 1、 -. "Pyrimidine, quinazoline, pteridine and triazine derivatives". Page/Page column 33. . Retrieved 2008/06/13.