Genfatinib-d3 (IMatinib-d3)

Base Information

• Chemical Name: Genfatinib-d3 (IMatinib-d3)
• CAS No.: 1134803-18-1
• Molecular Formula: C29H28D3N7O
• Molecular Weight: 496.588
• Mol file: 1134803-18-1.mol

Synonyms:Genfatinib-d3 (IMatinib-d3);Genfatinib-d3

Chemical Property of Genfatinib-d3 (IMatinib-d3)

Chemical Property:

• PSA: 86.28000
• LogP: 4.61210
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%+, ^*data from raw suppliers

Genfatinib-d3(Imatinib-d3) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Genfatinib-d3 (Imatinib-d3) is the labeled analogue of Genfatinib, a treatment of chronic myeloid leukemia (CML). It is a COVID19-related research product.

Technology Process of Genfatinib-d3 (IMatinib-d3)

There total 4 articles about Genfatinib-d3 (IMatinib-d3) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

iodomethane-d3 (865-50-9) + N-Desmethyl Imatinib (404844-02-6) → 4-[[4-(methyl-d3)-1-piperazinyl]methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide (1134803-18-1)

Guidance literature:

iodomethane-d3; N-Desmethyl Imatinib; With potassium carbonate; In N,N-dimethyl-formamide; at 22 ℃; for 1.5h;

With acetic anhydride; In N,N-dimethyl-formamide; for 0.333333h;

DOI:10.1016/j.bmc.2013.03.038

Reference yield:

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine (152460-10-1) → 4-[[4-(methyl-d3)-1-piperazinyl]methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide (1134803-18-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1,4-dioxane / 2.75 h / 22 - 34 °C

2.1: ethanol; water / 14 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 22 °C

3.2: 0.33 h

With potassium carbonate; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2013.03.038

Reference yield:

p-(chloromethyl)benzoyl chloride (876-08-4) → 4-[[4-(methyl-d3)-1-piperazinyl]methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide (1134803-18-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1,4-dioxane / 2.75 h / 22 - 34 °C

2.1: ethanol; water / 14 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 22 °C

3.2: 0.33 h

With potassium carbonate; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2013.03.038

upstream raw materials:

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

p-(chloromethyl)benzoyl chloride

4-(сhloromethyl)-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide hydrochloride

iodomethane-d3

Refernces