Benzenemethanamine, alpha-ethynyl-3-fluoro-, (alphaS)- (9CI)

Base Information

Chemical Name:Benzenemethanamine, alpha-ethynyl-3-fluoro-, (alphaS)- (9CI)
CAS No.:226699-04-3
Molecular Formula:C9H8FN
Molecular Weight:149.1649232
Hs Code.:
Mol file:226699-04-3.mol

Synonyms:Benzenemethanamine, alpha-ethynyl-3-fluoro-, (alphaS)- (9CI)

Suppliers and Price of Benzenemethanamine, alpha-ethynyl-3-fluoro-, (alphaS)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Benzenemethanamine, alpha-ethynyl-3-fluoro-, (alphaS)- (9CI)

Chemical Property:

PSA：26.02000
LogP:2.15900

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzenemethanamine, alpha-ethynyl-3-fluoro-, (alphaS)- (9CI)

There total 3 articles about Benzenemethanamine, alpha-ethynyl-3-fluoro-, (alphaS)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.9%

: 141-78-6
ethyl acetate

: 226698-97-1,226699-17-8
(+/-)-1-(3-fluorophenyl)-2-propynylamine

: 226699-04-3,226699-17-8
(R)-1-(3-Fluoro-phenyl)-prop-2-ynylamine

: 868752-10-7
(R)-N-acetyl-1-(3-fluorophenyl)prop-2-ynylamine

Guidance literature:: With lipase B from Candida antarctica NOVOZYM 435; In diethyl ether; at 20 ℃; for 47h;
DOI:10.1021/jo982513i

Reference yield:

: 226698-92-6
(+/-)-N-[1-(3-fluorophenyl)-2-propynyl]acetamide

: 226699-04-3,226699-17-8
(R)-1-(3-Fluoro-phenyl)-prop-2-ynylamine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrochloric acid

2: Candida antarctica lipase

With hydrogenchloride; Candida antarctica lipase;
DOI:10.1016/j.tetasy.2005.08.002

Reference yield:

: 2107-40-6,179249-17-3,179249-18-4
1-(3-fluorophenyl)-2-propyn-1-ol

: 226699-04-3,226699-17-8
(R)-1-(3-Fluoro-phenyl)-prop-2-ynylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / conc. sulfuric acid; sodium sulfate / 16 h / -20 - 20 °C

2: 76 percent / HCl / H₂O / 18 h / 70 °C

3: 46 percent / lipase B from Candida antarctica NOVOZYM 435 / diethyl ether / 47 h / 20 °C

With hydrogenchloride; lipase B from Candida antarctica NOVOZYM 435; sulfuric acid; sodium sulfate; In diethyl ether; water; 1: Substitution / 2: Deacetylation / 3: Acetylation;
DOI:10.1021/jo982513i