Ethanone, 1-[4-Methoxy-2-nitro-5-(phenylMethoxy)phenyl]-

Base Information

• Chemical Name: Ethanone, 1-[4-Methoxy-2-nitro-5-(phenylMethoxy)phenyl]-
• CAS No.: 516526-40-2
• Molecular Formula: C16H15NO5
• Molecular Weight: 301.299
• Hs Code.: 2914700090
• Mol file: 516526-40-2.mol

Synonyms:Ethanone, 1-[4-Methoxy-2-nitro-5-(phenylMethoxy)phenyl]-;1-(5-(Benzyloxy)-4-Methoxy-2-nitrophenyl)ethanone

Chemical Property of Ethanone, 1-[4-Methoxy-2-nitro-5-(phenylMethoxy)phenyl]-

Chemical Property:

• Boiling Point: 488.1±40.0 °C(Predicted)
• PSA: 81.35000
• Density: 1.247±0.06 g/cm3(Predicted)
• LogP: 3.90820
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

1-(5-(Benzyloxy)-4-methoxy-2-nitrophenyl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanone, 1-[4-Methoxy-2-nitro-5-(phenylMethoxy)phenyl]-

There total 4 articles about Ethanone, 1-[4-Methoxy-2-nitro-5-(phenylMethoxy)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1‐(3‐(benzyloxy)‐4‐methoxyphenyl)ethanone (23428-77-5) → 1‐(5‐(benzyloxy)‐4‐methoxy‐2‐nitrophenyl)ethanone (516526-40-2)

Guidance literature:

With sulfuric acid; nitric acid; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/ardp.201900101

Reference yield:

benzyl bromide (100-39-0) → 1‐(5‐(benzyloxy)‐4‐methoxy‐2‐nitrophenyl)ethanone (516526-40-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: nitric acid / acetic acid

With nitric acid; potassium carbonate; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.20150316

Reference yield:

3-hydroxy-4-methoxyacetophenone (6100-74-9) → 1‐(5‐(benzyloxy)‐4‐methoxy‐2‐nitrophenyl)ethanone (516526-40-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: nitric acid / acetic acid

With nitric acid; potassium carbonate; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.20150316

upstream raw materials:

1‐(3‐(benzyloxy)‐4‐methoxyphenyl)ethanone

benzyl bromide

3-hydroxy-4-methoxyacetophenone

Downstream raw materials:

1‐(2‐amino‐5‐(benzyloxy)‐4‐methoxyphenyl)ethanone